Alzheimer's disease (AD) is the most common neurodegenerative disease, which results in
dementia typically in the elderly. The disease is mainly characterized by the deposition of …

The nuclear factor erythroid-derived 2-related factor 2 (NFE2L2/Nrf2) is a pivotal facilitator of
cytoprotective responses against the oxidative/electrophilic insults. Upon activation, Nrf2 …

Background Infections by viruses including severe acute respiratory syndrome coronavirus 2
could cause organ inflammations such as myocarditis, pneumonia and encephalitis. Innate …

Alzheimer's disease (AD) is defined by the presence of abundant amyloid-β (Aβ) and tau
neuropathology. While this neuropathology is necessary for AD diagnosis, it is not sufficient …

The objective of this study was to investigate the neuroprotective and antioxidant effects of
ginsenoside compound K (CK) in a model of scopolamine hydrobromide-induced, memory …

Metformin, an anti-diabetes drug, has been recently emerging as a potential “anti-aging”
intervention based on its reported beneficial actions against aging in preclinical studies …

Diabetic kidney disease (DKD) has become a key cause of end-stage renal disease
worldwide. Inflammation and fibrosis have been shown to play important roles in the …

Background: As one of the widely used drugs for the management of type 2 diabetes
mellites (T2DM), metformin is increasingly believed to delay cognitive deterioration and …

Metformin is the safest and the most widely prescribed first-line therapy for managing
hyperglycemia due to different underlying causes, primarily type 2 diabetes mellitus. In …

While aging is the greatest risk factor for the development of neurodegenerative disease, the
role of aging in these diseases is poorly understood. In the inherited forms of these …