Ubiquitination, an important type of protein posttranslational modification (PTM), plays a
crucial role in controlling substrate degradation and subsequently mediates the “quantity” …

Aging has a profound and devastating effect on the brain. Old age is accompanied by
declining cognitive function and enhanced risk of brain diseases, including cancer and …

Human development requires intricate cell specification and communication pathways that
allow an embryo to generate and appropriately connect more than 200 different cell types …

Abstract FBXW7 (F-Box and WD Repeat Domain Containing 7)(also referred to as FBW7 or
hCDC4) is a component of the Skp1-Cdc53/Cullin-F-box-protein complex (SCF/β-TrCP). As …

Stem cells are characterized by their ability to self-renew and differentiate into many different
cell types. Research has focused primarily on how these processes are regulated at a …

Metalloenzymes are central to a wide range of essential biological activities, including
nucleic acid modification, protein degradation, and many others. The role of metalloenzymes …

Factor-induced reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) is
inefficient, complicating mechanistic studies. Here, we examined defined intermediate cell …

Metazoan organisms rely on conserved stress response pathways to alleviate adverse
conditions and preserve cellular integrity. Stress responses are particularly important in stem …

The ability to maintain a functional proteome, or proteostasis, declines during the ageing
process. Damaged and misfolded proteins accumulate with age, impairing cell function and …

Post-translational modifications (PTMs) are known to be essential mechanisms used by
eukaryotic cells to diversify their protein functions and dynamically coordinate their signaling …