Influenza viruses replicate within the nucleus of the host cell. This uncommon RNA virus trait
provides influenza with the advantage of access to the nuclear machinery during replication …

The genomes of influenza viruses consist of multiple segments of single-stranded negative-
sense RNA. Each of these segments is bound by the heterotrimeric viral RNA-dependent …

G-protein-coupled receptors (GPCRs) signal primarily through G proteins or arrestins.
Arrestin binding to GPCRs blocks G protein interaction and redirects signalling to numerous …

Influenza A viral ribonucleoprotein (vRNP) complexes comprise the eight genomic negative-
sense RNAs, each of which is bound to multiple copies of the vRNP and a trimeric viral …

Host innate recognition triggers key immune responses for viral elimination. The sensing
mechanism of hepatitis B virus (HBV), a DNA virus, and the subsequent downstream …

Influenza virus contains a single-stranded negative-sense RNA genome. Replication of the
genome is carried out by the viral RNA-dependent RNA polymerase in the context of the …

Influenza polymerase (FluPol) transcribes viral mRNA at the beginning of the viral life cycle
and initiates genome replication after viral protein synthesis. However, it remains poorly …

RNA viruses include many important human and animal pathogens, such as the influenza
viruses, respiratory syncytial virus, Ebola virus, measles virus and rabies virus. The …

Influenza A viruses (IAVs) constitute a major threat to human health. The IAV genome
consists of eight single-stranded viral RNA segments contained in separate viral …

Influenza virus polymerase uses a capped primer, derived by 'cap-snatching'from host pre-
messenger RNA, to transcribe its RNA genome into mRNA and a stuttering mechanism to …