The haematopoietic stem cell (HSC) microenvironment in the bone marrow, termed the
niche, ensures haematopoietic homeostasis by controlling the proliferation, self-renewal …

In terrestrial vertebrates, bone tissue constitutes the 'osteoimmune'system, which functions
as a locomotor organ and a mineral reservoir as well as a primary lymphoid organ where …

The treatment of low-risk primary prostate cancer entails active surveillance only, while high-
risk disease requires multimodal treatment including surgery, radiation therapy, and …

Interactions between the immune and central nervous systems strongly influence brain
health. Although the blood–brain barrier restricts this crosstalk, we now know that meningeal …

The bone marrow constitutes the primary site for life-long blood production and skeletal
regeneration. However, its cellular and spatial organization remains controversial. Here, we …

The bone marrow microenvironment has a key role in regulating haematopoiesis, but its
molecular complexity and response to stress are incompletely understood. Here we map the …

Stroma is a poorly defined non-parenchymal component of virtually every organ with key
roles in organ development, homeostasis, and repair. Studies of the bone marrow stroma …

Blood vessels form a versatile transport network that is best known for its critical roles in
processes such as tissue oxygenation, metabolism and immune surveillance. The …

Forming the inner layer of the vascular system, endothelial cells (ECs) facilitate a multitude
of crucial physiological processes throughout the body. Vascular ECs enable the vessel wall …

In mammals, hematopoietic stem cells (HSCs) engage in hematopoiesis throughout adult
life within the bone marrow, where they produce the mature cells necessary to maintain …