The understanding of lysosomes has come a long way since the initial discovery of their role
in degrading cellular waste. The lysosome is now recognized as a highly dynamic organelle …

The main aim of this review is to summarize the current state-of-art in the field of childhood
Neuronal Ceroid Lipofuscinosis (NCL), a group of rare neurodegenerative disorders. These …

Neuronal ceroid lipofuscinosis (NCLs) is a group of inherited neurodegenerative lysosomal
storage diseases that together represent the most common cause of dementia in children …

CLN2 disease (neuronal ceroid lipofuscinosis type 2) is a rare, autosomal recessive,
pediatric-onset, rapidly progressive neurodegenerative lysosomal storage disorder caused …

Lysosomal enzymes are synthesized in the endoplasmic reticulum (ER) and transferred to
the Golgi complex by interaction with the Batten disease protein CLN8 (ceroid lipofuscinosis …

The neuronal ceroid lipofuscinoses (NCLs) are a group of inherited neurodegenerative
lysosomal storage disorders (LSDs), traditionally grouped together based on shared clinical …

Collapsin response mediator proteins (CRMPs) are a family of ubiquitously expressed,
homologous phosphoproteins best known for coordinating cytoskeletal formation and …

Gene therapy is emerging as a valid method for the treatment of ovarian cancer, including
small interfering RNA (siRNA). Although it is so powerful, few targeting efficient gene …

The world health organisation has declared neurological disorders as one of the greatest
public health risks in the world today. Yet, despite this growing concern, the mechanisms …

Importance Biallelic variants inCLN3lead to a spectrum of diseases, ranging from severe
neurodegeneration with retinal involvement (juvenile neuronal ceroid lipofuscinosis) to …