The skin is comprised of different cell types with different proliferative capacities. Skin aging
occurs with chronological age and upon exposure to extrinsic factors such as photodamage …

Unusually large cancer cells with abnormal nuclei have been documented in the cancer
literature since 1858. For more than 100 years, they have been generally disregarded as …

Abstract Background and purpose Human Papillomavirus (HPV)-related head and neck
squamous cell carcinoma (HNSCC) respond favourably to radiotherapy as compared to …

Among the most intriguing and relevant questions in physiology is how developing tissues
correctly coordinate proliferation with differentiation. Endoreplication, in a broad sense, is a …

Progenitors in epithelial tissues, such as human skin epidermis, continuously make fate
decisions between self-renewal and differentiation. Here we show that the Super Elongation …

Aging is the single biggest risk factor for malignant transformation. Among the most common
age-associated malignancies are non-melanoma skin cancers, comprising the most …

The epidermis is a self-renewal epithelium continuously exposed to the genotoxic effects of
ultraviolet (UV) light, the main cause of skin cancer. Therefore, it needs robust self-protective …

Fifteen years ago, we reported that proto-oncogene MYC promoted differentiation of human
epidermal stem cells, a finding that was surprising to the MYC and the skin research …

To elucidate the molecular mechanisms underlying the pathogenesis and treatment of
human primary hepatocellular carcinoma (HCC), it is important to explore novel HCC …

Tumor suppressor p53 is a major cellular guardian of genome integrity, and its inactivation is
the most frequent genetic alteration in cancer, rising up to 80% in squamous cell carcinoma …