Noncanonical NF-κB signaling differs from canonical NF-κB signaling by being activated
through different cell surface receptors, cytoplasmic adaptors, and NF-κB dimers. Under …

Crohn's disease and ulcerative colitis are common and debilitating manifestations of
inflammatory bowel disease (IBD). IBD is characterized by a radical imbalance in the …

Microbial colonization of the infant gastrointestinal tract (GIT) begins at birth, is shaped by
the maternal microbiota, and is profoundly altered by antibiotic treatment. Antibiotic …

Atopic dermatitis (AD) is a pruritic inflammatory skin disease associated with a personal or
family history of allergy. The prevalence of AD is on the rise and estimated at∼ 17% in the …

Abstract Background We introduce the Basic Immune Simulator (BIS), an agent-based
model created to study the interactions between the cells of the innate and adaptive immune …

Our skin has a unique barrier function, which is imperative for the body's protection against
external pathogens and environmental insults. Although interacting closely and sharing …

Regulated activation of the cytokine TGF-β by integrins α v β 6 and α v β 8 expressed on
keratinocytes is required for residence of epidermal-resident memory T cells, but whether …

Eczema vaccinatum (EV) is a complication of smallpox vaccination that can occur in persons
with eczema/atopic dermatitis (AD), in which vaccinia virus disseminates to cause an …

The role that genetics play in response to infection or disease is becoming increasingly clear
as we learn more about immunogenetics and host–pathogen interactions. Here we report a …

Chronic skin inflammation in atopic eczema is associated with elevated expression of
proinflammatory genes and activation of innate immune responses in keratinocytes …