Mechanism of epithelial‐mesenchymal transition in cancer and its regulation by natural compounds

HL Ang, CD Mohan, MK Shanmugam… - Medicinal research …, 2023 - Wiley Online Library
Epithelial‐mesenchymal transition (EMT) is a complex process with a primordial role in
cellular transformation whereby an epithelial cell transforms and acquires a mesenchymal …

Long noncoding RNA (lncRNA)-mediated competing endogenous RNA networks provide novel potential biomarkers and therapeutic targets for colorectal cancer

L Wang, KB Cho, Y Li, G Tao, Z Xie, B Guo - International journal of …, 2019 - mdpi.com
Colorectal cancer (CRC) is the third most common cancer and has a high metastasis and
reoccurrence rate. Long noncoding RNAs (lncRNAs) play an important role in CRC growth …

MicroRNAs in cancer: biomarkers, functions and therapy

J Hayes, PP Peruzzi, S Lawler - Trends in molecular medicine, 2014 - cell.com
The emergence of microRNAs has been one of the defining developments in cancer biology
over the past decade, and the explosion of knowledge in this area has brought forward new …

[HTML][HTML] The lncRNA H19 promotes epithelial to mesenchymal transition by functioning as miRNA sponges in colorectal cancer

WC Liang, WM Fu, CW Wong, Y Wang, WM Wang… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Recently, the long non-coding RNA (lncRNA) H19 has been identified as an oncogenic
gene in multiple cancer types and elevated expression of H19 was tightly linked to …

Regulatory mechanisms of epigenetic miRNA relationships in human cancer and potential as therapeutic targets

KMT Arif, EK Elliott, LM Haupt, LR Griffiths - Cancers, 2020 - mdpi.com
Simple Summary By the virtue of targeting multiple genes, a microRNA (miRNA) can infer
variable consequences on tumorigenesis by appearing as both a tumour suppressor and …

EMT as the ultimate survival mechanism of cancer cells

N Tiwari, A Gheldof, M Tatari, G Christofori - Seminars in cancer biology, 2012 - Elsevier
Epithelial cancers make up the vast majority of cancer types and, during the transition from
benign adenoma to malignant carcinoma and metastasis, epithelial tumor cells acquire a de …

The regulatory role of microRNAs in EMT and cancer

A Zaravinos - Journal of oncology, 2015 - Wiley Online Library
The epithelial to mesenchymal transition (EMT) is a powerful process in tumor invasion,
metastasis, and tumorigenesis and describes the molecular reprogramming and phenotypic …

Multilayer control of the EMT master regulators

H Zheng, Y Kang - Oncogene, 2014 - nature.com
Metastasis is the leading cause of cancer-associated death in most tumor types. Metastatic
dissemination of cancer cells from the primary tumor is believed to be initiated by the …

Regulation of epithelial–mesenchymal and mesenchymal–epithelial transitions by microRNAs

S Lamouille, D Subramanyam, R Blelloch… - Current opinion in cell …, 2013 - Elsevier
Epithelial–mesenchymal transition (EMT) and the reverse process, mesenchymal–epithelial
transition (MET), are essential during development and in the regulation of stem cell …

A novel bifunctional anti-PD-L1/TGF-β Trap fusion protein (M7824) efficiently reverts mesenchymalization of human lung cancer cells

JM David, C Dominguez, KK McCampbell… - …, 2017 - Taylor & Francis
Mesenchymalization is a cellular and molecular program in which epithelial cells
progressively lose their well-differentiated phenotype and adopt mesenchymal …