Abstract Histone deacetylase (EC 3.5. 1.98–HDAC) is an amidohydrolase involved in
deacetylating the histone lysine residues for chromatin remodeling and thus plays a vital …

This review classifies drug‐design strategies successfully implemented in the development
of histone deacetylase (HDAC) inhibitors, which have many applications including cancer …

In the field of drug discovery, isoxazole is a five-membered heterocyclic moiety commonly
found in many commercially available drugs. In view of their enormous significance, it is …

Breast cancer is the second most leading cause of death among women. Multiple drugs
have been approved by FDA for the treatment of BC. The major drawbacks of existing drugs …

Isoxazol-5-ones and isoxazolidin-5-ones represent two important classes of heterocycles,
with several applications as bioactive compounds and as versatile building blocks for further …

Potassium phthalimide (PPI) is employed as an efficient and effective basic organocatalyst
for the one-pot three-component reaction of β-oxoesters with hydroxylamine hydrochloride …

The involvement of 1, 3-dipolar cycloaddition (1, 3-DP), double bond migration, metathesis,
and nitrile oxide (including in situ-generated nitrile oxide) as dipoles, together with the C= C …

Using Entinostat as a lead compound, 2-aminobenzamide and hydroxamate derivatives
have been designed and synthesized. The entire target compounds were investigated for …

Traditional approaches to bio‐orthogonal reaction discovery have focused on developing
reagent pairs that react with each other faster than they are metabolically degraded …

The development of functional materials exploiting excited-state intramolecular proton
transfer (ESIPT) requires a deep understanding of the push–pull balance on their reactivity …