The immense diversity of extracellular matrix (ECM) proteins confers distinct biochemical
and biophysical properties that influence cell phenotype. The ECM is highly dynamic as it is …

Biomedical scientists use chemistry-driven processes found in nature as an inspiration to
design biomaterials as promising diagnostic tools, therapeutic solutions, or tissue …

Currently, the clinical treatment of critical bone defects attributed to various causes remains
a great challenge, and repairing these defects with synthetic bone substitutes is the most …

The extracellular matrix (ECM) is a ubiquitous member of the body and is key to the
maintenance of tissue and organ integrity. Initially thought to be a bystander in many cellular …

Impaired wound healing is one of the unsolved problems of modern medicine, affecting
patients' quality of life and causing serious economic losses. Impaired wound healing can …

Durotaxis, the process by which cells follow gradients of extracellular mechanical stiffness,
has been proposed as a mechanism driving directed migration. Despite the lack of evidence …

Extracellular matrix (ECM) is comprised of different types of proteins, which change in
composition and ratios during morphogenesis and disease progression. ECM proteins …

Immune cells are highly dynamic and able to migrate through environments with diverse
biochemical and mechanical compositions. Their migration has classically been defined as …

Vascularized osteogenesis is essential for successful bone regeneration, yet its realization
during large size bone defect healing remains challenging due to the difficulty to couple …

Tissue regeneration is widespread in the animal kingdom. To date, key roles for different
molecular and cellular programs in regeneration have been described, but the ultimate …