The X-linked muscle-wasting disease Duchenne muscular dystrophy is caused by mutations
in the gene encoding dystrophin. There is currently no effective treatment for the disease; …

Dystrophin is the central protein of the dystrophin-glycoprotein complex (DGC) in skeletal
and heart muscle cells. Dystrophin connects the actin cytoskeleton to the extracellular matrix …

The ryanodine receptor (RyR) c corresponds to the sarcoplasmic reticulum (SR) Ca2+
channel (Inui et al., 1987; Imagawa et al., 1987). Its structure and function have been …

Dystroglycan is a central component of the dystrophin-glycoprotein complex (DGC), a
protein assembly that plays a critical role in a variety of muscular dystrophies. In order to …

Limb-girdle muscular dystrophy type 2D (LGMD 2D) is an autosomal recessive disorder
caused by mutations in the α-sarcoglycan gene. To determine how α-sarcoglycan deficiency …

Abstract β–sarcoglycan, a 43 kDa dystrophin–associated glycoprotein, is an integral
component of the dystrophin–glycoprotein complex. We have cloned human β–sarcoglycan …

Adhalin, the 50 kDa dystrophin-associated glycoprotein, is deficient In skeletal muscle of
patients having severe childhood autosomal recessive muscular dystrophy (SCARMD). In …

Cardiomyopathy (CM) is a primary degenerative disease of myocardium and is traditionally
categorized into hypertrophic and dilated CMs (HCM and DCM) according to its gross …

Dystroglycan connects the extracellular matrix and cytoskeleton. Key findings in the past
year indicate that dystroglycan interacts with a wider repertoire of extracellular ligands than …

Dystroglycan provides a crucial linkage between the cytoskeleton and the basement
membrane for skeletal muscle cells. Disruption of this linkage leads to various forms of …