Gold-based medicine: a paradigm shift in anti-cancer therapy?
CI Yeo, KK Ooi, ERT Tiekink - Molecules, 2018 - mdpi.com
A new era of metal-based drugs started in the 1960s, heralded by the discovery of potent
platinum-based complexes, commencing with cisplatin [(H3N) 2PtCl2], which are effective …
platinum-based complexes, commencing with cisplatin [(H3N) 2PtCl2], which are effective …
Coordination chemistry of thiazoles, isothiazoles and thiadiazoles
Thiazole derived compounds have great potential in medicinal-and agro-chemistries,
catalysis, cosmetic industry, corrosion protection, light harvesting, production of light-emitting …
catalysis, cosmetic industry, corrosion protection, light harvesting, production of light-emitting …
Heterocyclic-2-thione derivatives of group 10–12 metals: Coordination versatility, activation of CS (thione) bonds and biochemical potential
TS Lobana - Coordination Chemistry Reviews, 2021 - Elsevier
Heterocyclic thione derivatives of group 10–12 metals (Ni-Pt, Cu-Au, Zn-Hg) are reviewed in
this article. A survey of relatively recent coordination compounds of these metals are …
this article. A survey of relatively recent coordination compounds of these metals are …
Gold as a possible alternative to platinum-based chemotherapy for colon cancer treatment
Due to the increasing incidence and high mortality associated with colorectal cancer (CRC),
novel therapeutic strategies are urgently needed. Classic chemotherapy against CRC is …
novel therapeutic strategies are urgently needed. Classic chemotherapy against CRC is …
[HTML][HTML] Revisiting metallodrugs for the treatment of skin cancers
CM Manzano, DH Nakahata, REF de Paiva - Coordination Chemistry …, 2022 - Elsevier
Metallodrugs were classically screened against skin cancer (either in vitro or in vivo) at the
peak of the development of platinum anticancer agents. New systematic studies appeared in …
peak of the development of platinum anticancer agents. New systematic studies appeared in …
Preclinical gold complexes as oral drug candidates to treat leishmaniasis are potent trypanothione reductase inhibitors
LG Tunes, RE Morato, A Garcia, V Schmitz… - ACS Infectious …, 2020 - ACS Publications
The drugs currently used to treat leishmaniases have limitations concerning cost, efficacy,
and safety, making the search for new therapeutic approaches urgent. We found that the …
and safety, making the search for new therapeutic approaches urgent. We found that the …
Novel gold (I) complexes with 5-phenyl-1, 3, 4-oxadiazole-2-thione and phosphine as potential anticancer and antileishmanial agents
JDS Chaves, LG Tunes, CHJ Franco… - European Journal of …, 2017 - Elsevier
The current anticancer and antileishmanial drug arsenal presents several limitations
concerning their specificity, efficacy, costs and the emergence of drug-resistant cells lines …
concerning their specificity, efficacy, costs and the emergence of drug-resistant cells lines …
Novel antitumor adamantane–azole gold (I) complexes as potential inhibitors of thioredoxin reductase
A Garcia, RC Machado, RM Grazul, MTP Lopes… - JBIC Journal of …, 2016 - Springer
Gold complexes that could act as antitumor agents have attracted great attention.
Heterocyclic compounds and their metal complexes display a broad spectrum of …
Heterocyclic compounds and their metal complexes display a broad spectrum of …
1, 3, 4-Oxadiazole containing compounds as therapeutic targets for cancer therapy
MJ Ahsan - Mini Reviews in Medicinal Chemistry, 2022 - ingentaconnect.com
Background: Cancer is the first or second leading cause of premature death in 134 of 183
countries in the world. 1, 3, 4-Oxadiazoles are five membered heterocyclic rings containing …
countries in the world. 1, 3, 4-Oxadiazoles are five membered heterocyclic rings containing …
Lipophilic gold (I) complexes with 1, 3, 4-oxadiazol-2-thione or 1, 3-thiazolidine-2-thione moieties: synthesis and their cytotoxic and antimicrobial activities
AM de Almeida, BA de Oliveira, PP de Castro… - Biometals, 2017 - Springer
Novel lipophilic gold (I) complexes containing 1, 3, 4-oxadiazol-2-thione or 1, 3-thiazolidine-
2-thione derivatives were synthesized and characterized by IR, high resolution mass …
2-thione derivatives were synthesized and characterized by IR, high resolution mass …