Peroxiredoxins (Prxs) are a family of peroxidases that reduce peroxides, with a conserved
cysteine residue (the peroxidatic Cys) serving as the site of oxidation by peroxides …

Peroxiredoxins (Prxs), some of nature's dominant peroxidases, use a conserved Cys residue
to reduce peroxides. They are highly expressed in organisms from all kingdoms, and in …

Peroxiredoxin 2 (Prx2) is a 2-Cys peroxiredoxin extremely abundant in the erythrocyte. The
peroxidase activity was studied in a steady-state approach yielding an apparent KM of 2.4 …

Polyamines (PAs) are essential metabolites in eukaryotes, participating in a variety of
proliferative processes, and in trypanosomatid protozoa play an additional role in the …

Chagas disease and leishmaniasis are neglected tropical diseases caused by the
protozoan parasites Trypanosoma cruzi and Leishmania spp., respectively. They are among …

Significance: Chagas disease (CD) affects several million people in Latin America and is
spreading beyond its classical boundaries due to the migration of infected host and insect …

This article provides an overview about the recent advances in the dissection of the peroxide
metabolism of Trypanosomatidae. This family of protozoan organisms comprises the …

The first proteomic analysis of Trypanosoma cruzi resistance to Benznidazole (BZ) is
presented. The differential proteome of T. cruzi with selected in vivo resistance to …

Peroxiredoxins (Prx) are a family of anti‐oxidants that protect cells from metabolically
produced reactive oxygen species (ROS). The presence of these enzymes in the …

Cytosolic eukaryotic 2-Cys-peroxiredoxins have been widely reported to act as dual-function
proteins, either detoxifying reactive oxygen species or acting as chaperones to prevent …