PURPOSE To provide guidance on the use of opioids to manage pain from cancer or cancer
treatment in adults. METHODS A systematic review of the literature identified systematic …

This paper is the forty-fifth consecutive installment of the annual anthological review of
research concerning the endogenous opioid system, summarizing articles published during …

The US is grappling with an opioid epidemic, with millions of adults on long-term opioid
therapy (LTOT). Although patients often report pain relief and improved daily function with …

Introduction Substance abuse has become a worldwide health problem, leading to
numerous consequences such as social problems among family members, abnormal …

The prevalence of substance use globally is rising and is highest among men of
reproductive age. In Africa, and South and Central America, cannabis use disorder is most …

Opinion statement Opioids are an important treatment in managing cancer pain.
Uncontrolled pain can be detrimental to function and quality of life. Common adverse effects …

Objective To examine the effect of skoochies, an illicit cocktail drink, on testicular and sperm
function in male rats. Design Twenty-five adult male Wistar rats were assigned randomly into …

Over twenty years have passed since JLME published “The Girl Who Cried Pain: A Bias
Against Women in the Treatment of Pain.” This article revisits the conclusions drawn in that …

Background The adverse effects of short-term opioid analgesics are well known and
acknowledged; however, the spectrum of the sequelae of long-term use seems less clear …

Opioid drugs have been long known to induce different responses in males compared to
females, however, the molecular mechanisms underlying these effects are yet to be fully …