Non-coding RNAs in breast cancer: intracellular and intercellular communication
CM Klinge - Non-coding RNA, 2018 - mdpi.com
Non-coding RNAs (ncRNAs) are regulators of intracellular and intercellular signaling in
breast cancer. ncRNAs modulate intracellular signaling to control diverse cellular processes …
breast cancer. ncRNAs modulate intracellular signaling to control diverse cellular processes …
MicroRNA-based therapy and breast cancer: A comprehensive review of novel therapeutic strategies from diagnosis to treatment
Abstract MicroRNAs (miRNA) are 21–23 nucleotide molecules not translated into proteins
that bind and target the 3′ untranslated regions of mRNA. These characteristics make them …
that bind and target the 3′ untranslated regions of mRNA. These characteristics make them …
LGR5 promotes breast cancer progression and maintains stem-like cells through activation of Wnt/β-catenin signaling
The cancer stem cell (CSC) hypothesis suggests that a subset of cancer cells possesses
stem cell properties and is crucial in tumor initiation, metastasis, and drug resistance. To …
stem cell properties and is crucial in tumor initiation, metastasis, and drug resistance. To …
Epigenetic modification regulates tumor progression and metastasis through EMT
T Tan, P Shi, MN Abbas, Y Wang… - International …, 2022 - spandidos-publications.com
Epigenetics is the study of heritable molecular determinants that are independent of
phenotypic features. The epigenetic features include DNA methylation, histone …
phenotypic features. The epigenetic features include DNA methylation, histone …
Mouse models of breast cancer in preclinical research
MK Park, CH Lee, H Lee - Laboratory animal research, 2018 - Springer
Breast cancer remains the second leading cause of cancer death among woman,
worldwide, despite advances in identifying novel targeted therapies and the development of …
worldwide, despite advances in identifying novel targeted therapies and the development of …
[HTML][HTML] miR-29s: a family of epi-miRNAs with therapeutic implications in hematologic malignancies
A wealth of studies has highlighted the biological complexity of hematologic malignancies
and the role of dysregulated signal transduction pathways. Along with the crucial role of …
and the role of dysregulated signal transduction pathways. Along with the crucial role of …
Cell-free miRNAs as non-invasive biomarkers in breast cancer: Significance in early diagnosis and metastasis prediction
D Kashyap, H Kaur - Life sciences, 2020 - Elsevier
Breast cancer is one of the genetic diseases causing a high mortality among women around
the world. Despite the availability of advanced diagnostic tools and treatment strategies, the …
the world. Despite the availability of advanced diagnostic tools and treatment strategies, the …
[HTML][HTML] Nanomaterial-assisted CRISPR gene-engineering–A hallmark for triple-negative breast cancer therapeutics advancement
Triple-negative breast cancer (TNBC) is the most violent class of tumor and accounts for 20–
24% of total breast carcinoma, in which frequently rare mutation occurs in high frequency …
24% of total breast carcinoma, in which frequently rare mutation occurs in high frequency …
[HTML][HTML] miR-200c inhibits breast cancer proliferation by targeting KRAS
Abstract The microRNA, miR-200c, is involved in the tumorigenesis and progression of a
variety of cancers. The purpose of this study was to investigate the expression, mechanism …
variety of cancers. The purpose of this study was to investigate the expression, mechanism …
MicroRNAs: diverse mechanisms of action and their potential applications as cancer epi-therapeutics
A Sadakierska-Chudy - Biomolecules, 2020 - mdpi.com
Usually, miRNAs function post-transcriptionally, by base-pairing with the 3′ UTR of target
mRNAs, repressing protein synthesis in the cytoplasm. Furthermore, other regions including …
mRNAs, repressing protein synthesis in the cytoplasm. Furthermore, other regions including …