Non-coding RNAs (ncRNAs) are regulators of intracellular and intercellular signaling in
breast cancer. ncRNAs modulate intracellular signaling to control diverse cellular processes …

Abstract MicroRNAs (miRNA) are 21–23 nucleotide molecules not translated into proteins
that bind and target the 3′ untranslated regions of mRNA. These characteristics make them …

The cancer stem cell (CSC) hypothesis suggests that a subset of cancer cells possesses
stem cell properties and is crucial in tumor initiation, metastasis, and drug resistance. To …

Epigenetics is the study of heritable molecular determinants that are independent of
phenotypic features. The epigenetic features include DNA methylation, histone …

Breast cancer remains the second leading cause of cancer death among woman,
worldwide, despite advances in identifying novel targeted therapies and the development of …

A wealth of studies has highlighted the biological complexity of hematologic malignancies
and the role of dysregulated signal transduction pathways. Along with the crucial role of …

Breast cancer is one of the genetic diseases causing a high mortality among women around
the world. Despite the availability of advanced diagnostic tools and treatment strategies, the …

Triple-negative breast cancer (TNBC) is the most violent class of tumor and accounts for 20–
24% of total breast carcinoma, in which frequently rare mutation occurs in high frequency …

Abstract The microRNA, miR-200c, is involved in the tumorigenesis and progression of a
variety of cancers. The purpose of this study was to investigate the expression, mechanism …

Usually, miRNAs function post-transcriptionally, by base-pairing with the 3′ UTR of target
mRNAs, repressing protein synthesis in the cytoplasm. Furthermore, other regions including …