Summary The interleukin‐1 (IL‐1) family of cytokines and receptors is unique in immunology
because the IL‐1 family and Toll‐like receptor (TLR) families share similar functions. More …

Interleukin-1 (IL-1) is the prototypical inflammatory cytokine: two distinct ligands (IL-1α and IL-
1β) bind the IL-1 type 1 receptor (IL-1R1) and induce a myriad of secondary inflammatory …

Abstract Interleukin-1 (IL-1) is a highly active pro-inflammatory cytokine that lowers pain
thresholds and damages tissues. Monotherapy blocking IL-1 activity in autoinflammatory …

IL-1 is a master cytokine of local and systemic inflammation. With the availability of specific
IL-1 targeting therapies, a broadening list of diseases has revealed the pathologic role of IL …

The preventive treatment of latent tuberculosis infection (LTBI) is of great importance for the
elimination and control of tuberculosis (TB) worldwide, but existing screening methods for …

We conducted a systematic review and meta-analysis to compare the accuracy of the
QuantiFERON-TB® Gold In-Tube (QFT-G-IT) and the T-SPOT®. TB assays with the …

Despite the development of potentially curative chemotherapy, tuberculosis (TB) continues
to cause increasing worldwide morbidity and is a leading cause of human mortality in the …

Host immune response against Mycobacterium tuberculosis is mediated by cellular
immunity, in which cytokines and Th1 cells play a critical role. In the process of control of the …

New approaches to control the spread of tuberculosis (TB) are needed, including tools to
predict development of active TB from latent TB infection (LTBI). Recent studies have …

Diabetes has been recognized as an important risk factor for a variety of intracellular
bacterial infections, but research into the dysregulated immune mechanisms contributing to …