The reactive oxygen species (ROS)-producing enzyme NADPH oxidase (NOX) was first
identified in the membrane of phagocytic cells. For many years, its only known role was in …

Neurodegenerative disorders, such as Alzheimer's disease, are a global public health
burden with poorly understood aetiology. Neuroinflammation and oxidative stress (OS) are …

Innate immune responses, particularly activation of macrophages and microglia, are
increasingly implicated in CNS disorders. It is now appreciated that the heterogeneity of …

Spinal cord injury (SCI) is a significant cause of disability, and treatment alternatives that
generate beneficial outcomes and have no side effects are urgently needed. SCI may be …

Neuroinflammation and mitochondrial dysfunction are common features of chronic
neurodegenerative diseases of the central nervous system. Both conditions can lead to …

Oxidative stress is a common denominator in the pathology of neurodegenerative disorders
such as Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral …

Nicotinamide adenine dinucleotide phosphate (NAPDH) oxidase (NOX) is an enzyme
complex with the sole function of producing superoxide anion and reactive oxygen species …

NADPH oxidase as an important source of intracellular reactive oxygen species (ROS) has
gained enormous importance over the years, and the detailed structures of all the …

Traumatic brain injury (TBI) represents an important problem of global health. The damage
related to TBI is first due to the direct injury and then to a secondary phase in which …

Accumulating evidence has demonstrated that oxidative stress is associated with
depression. Our present study aimed at investigating the antidepressant effect and the …