Identification of PPA1 inhibitor candidates for potential repurposing in cancer medicine

M Menteş, C Yandım - Journal of Cellular Biochemistry, 2023 - Wiley Online Library
Abstract Inorganic pyrophosphatase 1 (PPA1) is pivotal to cellular metabolism as it facilitates
the hydrolysis of PPi—a by‐product of various metabolic processes that influence cell …

Spectroscopic insights with molecular docking and molecular dynamic simulation studies of anticancer drug 5-Fluorouracil targeting human pyruvate kinase m2

M Priyadarshinee, B Dehury, S Mishra… - Journal of …, 2024 - Taylor & Francis
This study was conducted to test the efficacy of 5-fluorouracil (5-FU) as an anticancer drug
against the human pyruvate kinase isozyme M2 (PKM2) using spectroscopic, molecular …

Classical molecular dynamics simulation identifies catechingallate as a promising antiviral polyphenol against MPOX palmitoylated surface protein

S Mishra, M Rout, MK Singh, B Dehury, S Pati - Computational Biology and …, 2024 - Elsevier
Cumulative global prevalence of the emergent monkeypox (MPX) infection in the non-
endemic countries has been professed as a global public health predicament. Lack of …

Molecular and phylogenetic characterization of the monkeypox outbreak in the South of Spain

CS Casimiro‐Soriguer, J Perez‐Florido… - Health Science …, 2024 - Wiley Online Library
Abstract Background and Aim Until the May 2022 Monkeypox (MPXV) outbreak, which
spread rapidly to many non‐endemic countries, the virus was considered a viral zoonosis …