Phenotypically identical cells can dramatically vary with respect to behavior during their
lifespan and this variation is reflected in their molecular composition such as the …

Gene expression analyses of bulk tissues often ignore cell type composition as an important
confounding factor, resulting in a loss of signal from lowly abundant cell types. In this review …

Single-cell genome, DNA methylome, and transcriptome sequencing methods have been
separately developed. However, to accurately analyze the mechanism by which …

Intratumor heterogeneity represents a major obstacle to effective cancer treatment and
personalized medicine. However, investigators are now elucidating intratumor heterogeneity …

Single-cell measurements and lineage-tracing experiments are revealing that phenotypic
cell-to-cell variability is often the result of deterministic processes, despite the existence of …

Immunoblotting (also known as Western blotting) combined with digital image analysis can
be a reliable method for analyzing the abundance of proteins and protein modifications, but …

The tumor microenvironment (TME) is critical for tumor progression. However, the
establishment and function of the TME remain obscure because of its complex cellular …

Summary Pre‐harvest sprouting (PHS), the germination of grain before harvest, is a serious
problem resulting in wheat yield and quality losses. Here, we mapped the PHS resistance …

Tissue development and homeostasis are regulated by opposing pro-survival and pro-death
signals. An interesting feature of the Tumor Necrosis Factor (TNF) family of ligands is that …

Human induced pluripotent stem cells (hiPSCs) and human embryonic stem cells (hESCs)
are promising candidate cell sources for regenerative medicine. However, despite the …