Research conducted in the past 15 years has yielded crucial insights that are reshaping our
understanding of the systems physiology of branched-chain amino acid (BCAA) metabolism …

The proportion of humans suffering from age‐related diseases is increasing around the
world, and creative solutions are needed to promote healthy longevity. Recent work has …

Despite intensive preventive cardiovascular disease (CVD) efforts, substantial residual CVD
risk remains even for individuals receiving all guideline-recommended interventions. Niacin …

Protein-restricted diets promote health and longevity in many species. While the precise
components of a protein-restricted diet that mediate the beneficial effects to longevity have …

Pharmacologic activation of branched-chain amino acid (BCAA) catabolism is protective in
models of heart failure (HF). How protection occurs remains unclear, although a causative …

Protein phosphatases and kinases control multiple cellular events including proliferation,
differentiation, and stress responses through regulating reversible protein phosphorylation …

Mesenchymal stem cells (MSCs) delivered into the post-ischemic heart milieu have a low
survival and retention rate, thus restricting the cardioreparative efficacy of MSC-based …

Background and aims We conducted a systematic review with meta-analysis of non-
prospective and prospective clinical studies to assess the effects of circulating branched …

Abstract Background and Aims To investigate the significance of 9 amino acids as risk
factors for incident cardiovascular disease events in 9584 Finnish men. Materials and …

Background In the failing heart, energy metabolism is shifted towards increased ketone body
oxidation. Nevertheless, the association of beta‐hydroxybutyrate (β‐OHB) with development …