A catalogue of signal molecules that interact with sensor kinases, chemoreceptors and transcriptional regulators

MA Matilla, F Velando, D Martín-Mora… - FEMS Microbiology …, 2022 - academic.oup.com
Bacteria have evolved many different signal transduction systems that sense signals and
generate a variety of responses. Generally, most abundant are transcriptional regulators …

[HTML][HTML] Identification of mycobacteriophage toxic genes reveals new features of mycobacterial physiology and morphology

CC Ko, GF Hatfull - Scientific Reports, 2020 - nature.com
Double-stranded DNA tailed bacteriophages typically code for 50–200 genes, of which 15–
35 are involved in virion structure and assembly, DNA packaging, lysis, and DNA …

The transcriptomic response to cannabidiol of Treponema denticola, a phytocannabinoid‐resistant periodontal pathogen

J Tan, GJ Lamont, M Sekula, HJ Hong… - Journal of Clinical …, 2024 - Wiley Online Library
Aim The use of cannabis, which contains multiple antimicrobials, may be a risk factor for
periodontitis. We hypothesized that multiple oral spirochetes would be phytocannabinoid …

A PadR family transcriptional repressor controls transcription of a trivalent metalloid resistance operon of Azospirillum halopraeferens strain Au 4

J Zhang, YF Wu, ST Tang, J Chen… - Environmental …, 2022 - Wiley Online Library
Abstract Methylarsenite [MAs (III)] is a highly toxic arsenical produced by some microbes as
an antibiotic. In this study, we demonstrate that a PadR family transcriptional regulator …

Characterization of the DNA binding domain of StbA, a key protein of a new type of DNA segregation system

V Quèbre, I Del Campo, A Cuevas, P Siguier… - Journal of Molecular …, 2022 - Elsevier
Low-copy-number plasmids require sophisticated genetic devices to achieve efficient
segregation of plasmid copies during cell division. Plasmid R388 uses a unique segregation …

Structural and biophysical characterization of PadR family protein Rv1176c of Mycobacterium tuberculosis H37Rv

V Yadav, M Zohib, S Singh, RK Pal, S Tripathi… - International Journal of …, 2024 - Elsevier
Rv1176c of Mycobacterium tuberculosis H37Rv belongs to the PadR-s1 subfamily of the
PadR family of protein. Rv1176c forms a stable dimer in solution. Its stability is characterized …

Redefining genetic essentiality in Mycobacterium tuberculosis

S Patil, A Palande, T Lodhiya, A Pandit, R Mukherjee - Gene, 2021 - Elsevier
Sequencing transposon mutant libraries have been pivotal in annotating essential and non-
essential genes in bacteria. This is particularly very helpful in the case of Mycobacterium …

Structural and functional characterization of peptidyl-tRNA hydrolase from Klebsiella pneumoniae

S Mundra, RK Pal, S Tripathi, A Jain, A Arora - Biochimica et Biophysica …, 2021 - Elsevier
Klebsiella pneumoniae is a member of the ESKAPE panel of pathogens that are top priority
to tackle AMR. Bacterial peptidyl tRNA hydrolase (Pth), an essential, ubiquitous enzyme …

Apo structure of the transcriptional regulator PadR from Bacillus subtilis: Structural dynamics and conserved Y70 residue

SC Park, WS Song, S Yoon - Biochemical and Biophysical Research …, 2020 - Elsevier
PadR is a bacterial transcriptional regulator that controls the expression of phenolic acid
decarboxylase (PadC) in response to phenolic acids to prevent their toxic effects. During …

Expression, purification and crystallization of the putative transcriptional regulator MSMEG_6227 from Mycobacteria

S Halas - 2021 - dspace.jcu.cz
MSMEG_6227, a putative transcriptional regulator from Mycobacterium smegmatis, was
cloned and expressed in E. coli BL21 cells. The expressed protein was purified by …