Vascularization and angiogenesis in tissue engineering: beyond creating static networks

J Rouwkema, A Khademhosseini - Trends in biotechnology, 2016 - cell.com
Engineered tissues need a vascular network to supply cells with nutrients and oxygen after
implantation. A network that can connect to the vasculature of the patient after implantation …

Organ‐on‐a‐chip platforms: a convergence of advanced materials, cells, and microscale technologies

S Ahadian, R Civitarese, D Bannerman… - Advanced …, 2018 - Wiley Online Library
Significant advances in biomaterials, stem cell biology, and microscale technologies have
enabled the fabrication of biologically relevant tissues and organs. Such tissues and organs …

3D printing of microgel scaffolds with tunable void fraction to promote cell infiltration

AJ Seymour, S Shin… - Advanced healthcare …, 2021 - Wiley Online Library
Granular, microgel‐based materials have garnered interest as promising tissue engineering
scaffolds due to their inherent porosity, which can promote cell infiltration. Adapting these …

Collective cell migration: guidance principles and hierarchies

A Haeger, K Wolf, MM Zegers, P Friedl - Trends in cell biology, 2015 - cell.com
Collective cell migration results from the establishment and maintenance of collective
polarization, mechanocoupling, and cytoskeletal kinetics. The guidance of collective cell …

Microfluidic assay for simultaneous culture of multiple cell types on surfaces or within hydrogels

Y Shin, S Han, JS Jeon, K Yamamoto… - Nature protocols, 2012 - nature.com
This protocol describes a simple but robust microfluidic assay combining three-dimensional
(3D) and two-dimensional (2D) cell culture. The microfluidic platform comprises hydrogel …

3D microvascularized tissue models by laser‐based cavitation molding of collagen

A Enrico, D Voulgaris, R Östmans… - Advanced …, 2022 - Wiley Online Library
Abstract 3D tissue models recapitulating human physiology are important for fundamental
biomedical research, and they hold promise to become a new tool in drug development. An …

Generation of multi-scale vascular network system within 3D hydrogel using 3D bio-printing technology

VK Lee, AM Lanzi, H Ngo, SS Yoo, PA Vincent… - Cellular and molecular …, 2014 - Springer
Although 3D bio-printing technology has great potential in creating complex tissues with
multiple cell types and matrices, maintaining the viability of thick tissue construct for tissue …

Organ-on-a-chip technology: a novel approach to investigate cardiovascular diseases

V Paloschi, M Sabater-Lleal… - Cardiovascular …, 2021 - academic.oup.com
The development of organs-on-chip (OoC) has revolutionized in vitro cell-culture
experiments by allowing a better mimicry of human physiology and pathophysiology that has …

Coaxial cell printing of freestanding, perfusable, and functional in vitro vascular models for recapitulation of native vascular endothelium pathophysiology

G Gao, JY Park, BS Kim, J Jang… - Advanced healthcare …, 2018 - Wiley Online Library
Abstract 3D printing technology is used to produce channels within hydrogels followed by
endothelial cells (ECs)‐seeding to establish in vitro vascular models. However, as built‐in …

Tumour-on-a-chip: microfluidic models of tumour morphology, growth and microenvironment

HF Tsai, A Trubelja, AQ Shen… - Journal of The Royal …, 2017 - royalsocietypublishing.org
Cancer remains one of the leading causes of death, albeit enormous efforts to cure the
disease. To overcome the major challenges in cancer therapy, we need to have a better …