Shadow enhancers are seemingly redundant transcriptional cis-regulatory elements that
regulate the same gene and drive overlapping expression patterns. Recent studies have …

Adult neurogenesis is a widespread trait of vertebrates; however, the degree of this ability
and the underlying activity of the adult neural stem cells differ vastly among species. In …

This paper, in the form of a frequently asked questions page (FAQ), addresses outstanding
questions about “shadow enhancers”, quasi‐redundant cis‐regulatory elements, and their …

Neurons share many features in common but are distinguished by expression of phenotypic
characteristics that define their specific function, location, or connectivity. One aspect of …

Background Lim-HD proteins control crucial aspects of neuronal differentiation, including
subtype identity and axonal guidance. The Lim-HD proteins Lhx2/9 and Lhx1/5 are …

In mouse ear development, two bHLH genes, Atoh1 and Neurog1, are essential for hair cell
and sensory neuron differentiation. Evolution converted the original simple atonal …

The proneural basic helix–loop–helix (bHLH) transcription factor neurogenin1 (Neurog1)
plays a pivotal role in neuronal differentiation during mammalian development. The …

The continuous replacement of neurons in the olfactory epithelium provides an
advantageous model for investigating neuronal differentiation and maturation. By calculating …

Green fluorescent protein (GFP) transgenic zebrafish technology has been employed to
directly visualize and analyze dynamic developmental processes, such as cell migration and …

Neural basic helix-loop-helix (bHLH) transcription factors are crucial in regulating the
differentiation and neuronal subtype specification of neurons. Precisely how these …