Genetic landscape and biomarkers of hepatocellular carcinoma

J Zucman-Rossi, A Villanueva, JC Nault, JM Llovet - Gastroenterology, 2015 - Elsevier
Hepatocellular carcinoma (HCC) has emerged as a major cause of cancer-related death. Its
mortality has increased in Western populations, with a minority of patients diagnosed at …

Insulin-like growth factor (IGF) system in liver diseases

A Adamek, A Kasprzak - International journal of molecular sciences, 2018 - mdpi.com
Hepatocyte differentiation, proliferation, and apoptosis are affected by growth factors
produced in liver. Insulin-like growth factor 1 and 2 (IGF1 and IGF2) act in response to …

Deep learning–based multi-omics integration robustly predicts survival in liver cancer

K Chaudhary, OB Poirion, L Lu, LX Garmire - Clinical Cancer Research, 2018 - AACR
Identifying robust survival subgroups of hepatocellular carcinoma (HCC) will significantly
improve patient care. Currently, endeavor of integrating multi-omics data to explicitly predict …

Hepatocellular carcinoma: epidemiology and molecular carcinogenesis

HB El–Serag, KL Rudolph - Gastroenterology, 2007 - Elsevier
Primary liver cancer, which consists predominantly of hepatocellular carcinoma (HCC), is
the fifth most common cancer worldwide and the third most common cause of cancer …

Integrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinoma

Y Hoshida, SMB Nijman, M Kobayashi, JA Chan… - Cancer research, 2009 - AACR
Hepatocellular carcinoma (HCC) is a highly heterogeneous disease, and prior attempts to
develop genomic-based classification for HCC have yielded highly divergent results …

Liver cancer: approaching a personalized care

J Bruix, KH Han, G Gores, JM Llovet… - Journal of …, 2015 - journal-of-hepatology.eu
The knowledge and understanding of all aspects of liver cancer [this including
hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA)] have …

[PDF][PDF] Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets

S Boyault, DS Rickman, A De Reyniès… - …, 2007 - Wiley Online Library
Hepatocellular carcinomas (HCCs) are a heterogeneous group of tumors that differ in risk
factors and genetic alterations. We further investigated transcriptome‐genotype‐phenotype …

[HTML][HTML] Targeting the insulin-like growth factor pathway in hepatocellular carcinoma

M Enguita-Germán, P Fortes - World journal of hepatology, 2014 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths
worldwide. Only 30%-40% of the patients with HCC are eligible for curative treatments …

[PDF][PDF] Molecular targeted therapies in hepatocellular carcinoma

JM Llovet, J Bruix - Hepatology, 2008 - Wiley Online Library
Hepatocellular carcinoma (HCC) is a complex and heterogeneous tumor with several
genomic alterations. There is evidence of aberrant activation of several signaling cascades …

Focal Gains of VEGFA and Molecular Classification of Hepatocellular Carcinoma

DY Chiang, A Villanueva, Y Hoshida, J Peix, P Newell… - Cancer research, 2008 - AACR
Hepatocellular carcinomas represent the third leading cause of cancer-related deaths
worldwide. The vast majority of cases arise in the context of chronic liver injury due to …