Neuroinflammation mechanisms of neuromodulation therapies for anxiety and depression

B Guo, M Zhang, W Hao, Y Wang, T Zhang… - Translational …, 2023 - nature.com
Mood disorders are associated with elevated inflammation, and the reduction of symptoms
after multiple treatments is often accompanied by pro-inflammation restoration. A variety of …

Understanding anxiety symptoms as aberrant defensive responding along the threat imminence continuum

R Abend - Neuroscience & Biobehavioral Reviews, 2023 - Elsevier
Threat-anticipatory defensive responses have evolved to promote survival in a dynamic
world. While inherently adaptive, aberrant expression of defensive responses to potential …

[HTML][HTML] Polystyrene micro-and nano-particle coexposure injures fetal thalamus by inducing ROS-mediated cell apoptosis

D Yang, J Zhu, X Zhou, D Pan, S Nan, R Yin… - Environment …, 2022 - Elsevier
The adverse effects of plastic on adult animal and human health have been receiving
increasing attention. However, its potential toxicity to fetuses has not been fully elucidated …

Anxious individuals shift emotion control from lateral frontal pole to dorsolateral prefrontal cortex

B Bramson, S Meijer, A van Nuland, I Toni… - Nature …, 2023 - nature.com
Anxious individuals consistently fail in controlling emotional behavior, leading to excessive
avoidance, a trait that prevents learning through exposure. Although the origin of this failure …

[HTML][HTML] CB2R activation ameliorates late adolescent chronic alcohol exposure-induced anxiety-like behaviors during withdrawal by preventing morphological …

J Li, H Wang, D Liu, X Li, L He, J Pan, Q Shen… - Brain, Behavior, and …, 2023 - Elsevier
Background Chronic alcohol exposure (CAE) during late adolescence increases the risk of
anxiety development. Alcohol-induced prefrontal cortex (PFC) microglial activation …

Persistent dissociation and its neural correlates in predicting outcomes after trauma exposure

LAM Lebois, NG Harnett… - American journal of …, 2022 - Am Psychiatric Assoc
Objective: Dissociation, a disruption or discontinuity in psychological functioning, is often
linked with worse psychiatric symptoms; however, the prognostic value of dissociation after …

Regional, circuit and network heterogeneity of brain abnormalities in psychiatric disorders

A Segal, L Parkes, K Aquino, SM Kia, T Wolfers… - Nature …, 2023 - nature.com
The substantial individual heterogeneity that characterizes people with mental illness is
often ignored by classical case–control research, which relies on group mean comparisons …

Measuring anxiety-like behaviors in rodent models of traumatic brain injury

LB Tucker, JT McCabe - Frontiers in behavioral neuroscience, 2021 - frontiersin.org
Anxiety is a common complaint following acquired traumatic brain injury (TBI). However, the
measurement of dysfunctional anxiety behavioral states following experimental TBI in …

Multi-modal biomarkers of repetitive head impacts and traumatic encephalopathy syndrome: A clinicopathological case series

BM Asken, JA Tanner, L VandeVrede… - Journal of …, 2022 - liebertpub.com
Traumatic encephalopathy syndrome (TES) criteria were developed to aid diagnosis of
chronic traumatic encephalopathy (CTE) pathology during life. Interpreting clinical and …

Agomelatine for the treatment of generalized anxiety disorder: focus on its distinctive mechanism of action

MJ Millan - Therapeutic Advances in Psychopharmacology, 2022 - journals.sagepub.com
Generalized anxiety disorder (GAD), the most frequently diagnosed form of anxiety, is
usually treated by cognitive-behavioural approaches or medication; in particular …