New insights into the physiological role of endoplasmic reticulum-associated degradation
Many human diseases are associated with mutations causing protein misfolding and
aggregation in the endoplasmic reticulum (ER). ER-associated degradation (ERAD) is a …
aggregation in the endoplasmic reticulum (ER). ER-associated degradation (ERAD) is a …
The critical role of GRP78 in physiologic and pathologic stress
KT Pfaffenbach, AS Lee - Current opinion in cell biology, 2011 - Elsevier
GRP78 is a major endoplasmic reticulum chaperone as well as a master regulator of the
unfolded protein response. In addition to playing an essential role in early embryonic …
unfolded protein response. In addition to playing an essential role in early embryonic …
[HTML][HTML] SEL1L–HRD1 endoplasmic reticulum-associated degradation controls STING-mediated innate immunity by limiting the size of the activable STING pool
Stimulator of interferon genes (STING) orchestrates the production of proinflammatory
cytokines in response to cytosolic double-stranded DNA; however, the pathophysiological …
cytokines in response to cytosolic double-stranded DNA; however, the pathophysiological …
The metabolic ER stress sensor IRE1α suppresses alternative activation of macrophages and impairs energy expenditure in obesity
Obesity is associated with metabolic inflammation and endoplasmic reticulum (ER) stress,
both of which promote metabolic disease progression. Adipose tissue macrophages (ATMs) …
both of which promote metabolic disease progression. Adipose tissue macrophages (ATMs) …
[HTML][HTML] Thbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated autophagy
The thrombospondin (Thbs) family of secreted matricellular proteins are stress-and injury-
induced mediators of cellular attachment dynamics and extracellular matrix protein …
induced mediators of cellular attachment dynamics and extracellular matrix protein …
[HTML][HTML] A J-protein co-chaperone recruits BiP to monomerize IRE1 and repress the unfolded protein response
N Amin-Wetzel, RA Saunders, MJ Kamphuis, C Rato… - Cell, 2017 - cell.com
When unfolded proteins accumulate in the endoplasmic reticulum (ER), the unfolded protein
response (UPR) increases ER-protein-folding capacity to restore protein-folding …
response (UPR) increases ER-protein-folding capacity to restore protein-folding …
[HTML][HTML] Biallelic Cys141Tyr variant of SEL1L is associated with neurodevelopmental disorders, agammaglobulinemia, and premature death
Suppressor of lin-12-like–HMG-CoA reductase degradation 1 (SEL1L-HRD1) ER-
associated degradation (ERAD) plays a critical role in many physiological processes in …
associated degradation (ERAD) plays a critical role in many physiological processes in …
[HTML][HTML] Hypomorphic variants of SEL1L-HRD1 ER-associated degradation are associated with neurodevelopmental disorders
Recent studies using cell type–specific knockout mouse models have improved our
understanding of the pathophysiological relevance of suppressor of lin-12-like–HMG-CoA …
understanding of the pathophysiological relevance of suppressor of lin-12-like–HMG-CoA …
[HTML][HTML] Pharmacological targeting of MYC-regulated IRE1/XBP1 pathway suppresses MYC-driven breast cancer
The unfolded protein response (UPR) is a cellular homeostatic mechanism that is activated
in many human cancers and plays pivotal roles in tumor progression and therapy resistance …
in many human cancers and plays pivotal roles in tumor progression and therapy resistance …
IRE1α is an endogenous substrate of endoplasmic-reticulum-associated degradation
Endoplasmic reticulum (ER)-associated degradation (ERAD) represents a principle quality
control mechanism to clear misfolded proteins in the ER; however, its physiological …
control mechanism to clear misfolded proteins in the ER; however, its physiological …