[HTML][HTML] Insights from deep sequencing of the HBV genome—unique, tiny, and misunderstood
Hepatitis B virus (HBV) is a unique, tiny, partially double-stranded, reverse-transcribing DNA
virus with proteins encoded by multiple overlapping reading frames. The substitution rate is …
virus with proteins encoded by multiple overlapping reading frames. The substitution rate is …
Phylogeny and molecular evolution of the hepatitis C virus
P Jackowiak, K Kuls, L Budzko, A Mania… - Infection, Genetics and …, 2014 - Elsevier
The hepatitis C virus (HCV) is a globally prevalent human pathogen that causes persistent
liver infections in most infected individuals. HCV is classified into seven phylogenetically …
liver infections in most infected individuals. HCV is classified into seven phylogenetically …
HCV substitutions and IL28B polymorphisms on outcome of peg-interferon plus ribavirin combination therapy
CN Hayes, M Kobayashi, N Akuta, F Suzuki, H Kumada… - Gut, 2011 - gut.bmj.com
Background and aims A number of recent studies have shown that human polymorphisms
near the IL28B type III interferon (IFNλ) gene influence the response to peg-interferon plus …
near the IL28B type III interferon (IFNλ) gene influence the response to peg-interferon plus …
Analysis of HCV quasispecies dynamic under selective pressure of combined therapy
ACG Jardim, C Bittar, RPA Matos, LHT Yamasaki… - BMC infectious …, 2013 - Springer
Background The quasispecies composition of Hepatitis C virus (HCV) could have important
implications with regard to viral persistence and response to interferon-based therapy. The …
implications with regard to viral persistence and response to interferon-based therapy. The …
Prevalence of Naturally-Occurring NS5A and NS5B Resistance-Associated Substitutions in Iranian Patients With Chronic Hepatitis C Infection
Background Hepatitis C virus (HCV), non-structural 5A (NS5A), and non-structural 5B
(NS5B) resistance-associated substitutions (RASs) are the main causes of failure to direct …
(NS5B) resistance-associated substitutions (RASs) are the main causes of failure to direct …
New insights regarding HCV-NS5A structure/function and indication of genotypic differences
Background HCV is prevalent throughout the world. It is a major cause of chronic liver
disease. There is no effective vaccine and the most common therapy, based on …
disease. There is no effective vaccine and the most common therapy, based on …
On hepatitis C virus evolution: the interaction between virus and host towards treatment outcome
Background Hepatitis C is a disease spread throughout the world. Hepatitis C virus (HCV),
the etiological agent of this disease, is a single-stranded positive RNA virus. Its genome …
the etiological agent of this disease, is a single-stranded positive RNA virus. Its genome …
The relationships between IFNL4 genotype, intrahepatic interferon‐stimulated gene expression and interferon treatment response differs in HCV‐1 compared with …
JA Holmes, M Congiu, S Bonanzinga… - Alimentary …, 2015 - Wiley Online Library
Background The biological mechanism underlying the association between IFNL4/IFNL3
polymorphism and peginterferon/ribavirin (PR) response in HCV‐1 is thought to involve …
polymorphism and peginterferon/ribavirin (PR) response in HCV‐1 is thought to involve …
Response to combination therapy of HCV 3a infected Pakistani patients and the role of NS5A protein
Abstract Background Hepatitis C virus (HCV) genotype 3a is known to show comparatively
better response to combination therapy than genotype 1 and 4. Mutations within NS5A gene …
better response to combination therapy than genotype 1 and 4. Mutations within NS5A gene …
Copy number variation of genes involved in the hepatitis C virus-human interactome
L Budzko, M Marcinkowska-Swojak, P Jackowiak… - Scientific Reports, 2016 - nature.com
Copy number variation (CNV) is a newly discovered form of intra-species genetic
polymorphism that is defined as deletions or duplications of genome segments ranging from …
polymorphism that is defined as deletions or duplications of genome segments ranging from …