Genetics plays a role, to a greater or lesser extent, in all diseases. Variations in our DNA and
differences in how that DNA functions (alone or in combinations), alongside the environment …

Unfolded stress response (UPR) is a conserved cellular pathway involved in protein quality
control to maintain homeostasis under different conditions and disease states characterized …

The discovery of the Cystic fibrosis (CF) gene in 1989 has paved the way for incredible
progress in treating the disease such that the mean survival age of individuals living with CF …

An improved understanding of the cystic fibrosis (CF) transmembrane conductance regulator
(CFTR) protein structure and the consequences of CFTR gene mutations have allowed the …

Background The efficacy, safety, and tolerability of lumacaftor and ivacaftor are established
in patients aged 6 years and older with cystic fibrosis, homozygous for the F508del-CFTR …

Genetic defects in cystic fibrosis (CF) transmembrane conductance regulator (CFTR) gene
cause CF. Infants with CFTR mutations show a peribronchial neutrophil infiltration prior to …

Recent studies of human respiratory secretions using culture-independent techniques have
found a surprisingly diverse array of microbes. Interactions among these community …

Cystic fibrosis (CF) affects 70,000 patients worldwide. Morbidity and mortality in CF is largely
caused by lung complications due to the triad of impaired mucociliary clearance, microbial …

The advent of the knowledge on human genetics, by the identification of disease-associated
variants, culminated in the understanding of human variability. With the genetic knowledge …

The fecal morphology, defecation frequency, bowel function, intestinal motility, and fecal
bacterial composition were evaluated to investigate the laxative effect of probiotic chocolate …