The role of blood rheology in sickle cell disease

P Connes, T Alexy, J Detterich, M Romana… - Blood reviews, 2016 - Elsevier
Studies performed in the last decades have highlighted the need to better understand the
contribution of the endothelium, vascular function, oxidative stress, inflammation …

The role of leukotrienes in immunopathogenesis of rheumatoid arthritis

B Yousefi, F Jadidi-Niaragh, G Azizi… - Modern …, 2014 - academic.oup.com
Rheumatoid arthritis (RA) is a chronic inflammatory disorder of joints for which there is no
strict cure. However, conventional medications can reduce inflammation, relieve pain, and …

[HTML][HTML] Eicosanoid pathway on host resistance and inflammation during Mycobacterium tuberculosis infection is comprised by LTB4 reduction but not PGE2 …

CA Sorgi, EM Soares, RS Rosada… - … et Biophysica Acta (BBA …, 2020 - Elsevier
The functions of eicosanoids, a family of potent biologically active lipid mediators, are not
restricted to inflammatory responses and they also act as mediators of the pathogenesis …

The inhibition of 5-Lipoxygenase (5-LO) products leukotriene B4 (LTB4) and cysteinyl leukotrienes (cysLTs) modulates the inflammatory response and improves …

FR Guimaraes, H Sales-Campos, V Nardini… - Clinical …, 2018 - Elsevier
To analyze the participation of the enzyme 5-lipoxygenase (5-LO) in skin repair, WT wounds
were compared to those in 5-LO deficient mice (5-LO−/−), which presented faster closure …

[HTML][HTML] Spirulina polysaccharide induces the metabolic shifts and gut microbiota change of lung cancer in mice

Y Lu, B Peng, Y Lin, Q Lin, X Xia, S Zhong, L Luo… - Current Research in …, 2022 - Elsevier
A polysaccharide obtained from Spirulina (PSP) and its effect on lung cancer in mice was
investigated. Our results indicate that the tumor volume and weight of the lung cancer …

Therapeutic potential of biodegradable microparticles containing Punica granatum L. (pomegranate) in murine model of asthma

JFF de Oliveira, DV Garreto, MCP da Silva… - Inflammation …, 2013 - Springer
Objective and design Among the options for treatment of diseases affecting the respiratory
system, especially asthma, drug delivering systems for intranasal application represent an …

20-Hydroxy- and 20-carboxy-leukotriene (LT) B4 downregulate LTB4-mediated responses of human neutrophils and eosinophils

AS Archambault, S Poirier, JS Lefebvre… - Journal of Leukocyte …, 2019 - academic.oup.com
Abstract Leukotriene B4 (LTB4) plays a prominent role in innate immunity as it induces
phagocyte recruitment, the release of antimicrobial effectors, and as it potentiates the …

Antileishmanial and Immunomodulatory Effect of Babassu‐Loaded PLGA Microparticles: A Useful Drug Target to Leishmania amazonensis Infection

MCP Silva, JM Brito, AS Ferreira… - Evidence‐Based …, 2018 - Wiley Online Library
The immunological and the anti-Leishmania amazonensis activity of babassu‐loaded poly
(lactic‐co‐glycolic acid)[PLGA] microparticles was evaluated. The anti‐Leishmania activity …

Immunopharmacological role of the leukotriene receptor antagonists and inhibitors of leukotrienes generating enzymes in multiple sclerosis

A Mirshafiey, F Jadidi-Niaragh - Immunopharmacology and …, 2010 - Taylor & Francis
Background and aim: Multiple sclerosis (MS) is a chronic inflammatory disease that involves
central nervous system, and is generally associated with demyelination and axonal lesion …

Pulmonary drug delivery system: a novel approach for drug delivery

A Singh, R Malviya, P K. Sharma - Current Drug Therapy, 2011 - benthamdirect.com
In present study authors review all aspects of pulmonary drug delivery system; including
need of drug delivery, different approaches for drug delivery and recent advancement in …