Rheumatoid arthritis (RA) is characterized by inflammation and destruction of bone and
cartilage in affected joints. Autoimmune responses lead to increased osteoclastic bone …

Alzheimer's disease (AD) is the most common neurodegenerative disease, with
characteristic extracellular amyloid-β (Aβ) deposition and intracellular accumulation of …

Tumor immune microenvironment (TIME) include tumor cells, immune cells, cytokines, etc.
The interactions between these components, which are divided into anti-tumor and pro …

Regulatory T (Treg) cells, although vital for immune homeostasis, also represent a major
barrier to anti-cancer immunity, as the tumour microenvironment (TME) promotes the …

Background Non-small-cell lung cancer (NSCLC) is terminal in most patients with locally
advanced stage disease. We aimed to assess the antitumour activity and safety of …

Chimeric antigen receptor (CAR)-T cell therapy has revolutionized the treatment of
hematologic malignancies. Approximately half of patients with refractory large B cell …

Immunotherapy has revolutionized cancer treatment and rejuvenated the field of tumor
immunology. Several types of immunotherapy, including adoptive cell transfer (ACT) and …

Regulatory T cells (Tregs) characterized by the expression of the master transcription factor
forkhead box protein p3 (Foxp3) suppress anticancer immunity, thereby hindering protective …

Infection with the severe acute respiratory syndrome novel coronavirus produces a clinical
syndrome known as 2019 novel coronavirus disease (COVID-19). When severe, COVID-19 …

The immune system of patients infected by SARS-CoV-2 is severely impaired. Detailed
investigation of T cells and cytokine production in patients affected by COVID-19 pneumonia …