The benzene moiety is the most prevalent ring system in marketed drugs, underscoring its
historic popularity in drug design either as a pharmacophore or as a scaffold that projects …

Oral administration is an appealing route of delivering cancer treatments. However, the
gastrointestinal tract is characterized by specific and efficient physical, chemical, and …

Highlights•Orally delivered drug products gradually continue to exceed the Rule-of-five on
Molecular Weight and clogP.•New predictive descriptors and tools, advanced chemistry and …

Drug-drug interactions (DDIs) arising from the perturbation of drug metabolising enzyme
activities represent both a clinical problem and a potential economic loss for the …

The side effects of cancer therapy continue to cause significant health and cost burden to the
patient, their friends and family, and governments. A major barrier in the way in which these …

Kinase inhibitors (KIs) are a rapidly expanding class of drugs used primarily for the treatment
of cancer. Data relating to the inhibition of UDP-glucuronosyltransferase (UGT) enzymes by …

Advances in pharmacogenomics (PGx) have the potential to transform healthcare by
allowing precision medicine to become a reality. However, PGx knowledge is new, complex …

Global QSAR modelling was performed to predict the pIC50 values of 233 diverse
heterocyclic compounds as BTK inhibitors with the Monte Carlo algorithm of CORAL …

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease,
affecting approximately one-third of the global population. Most affected individuals …

Tyrosine kinase inhibitors (TKIs) are used as targeted therapy for cancer by inhibiting the
signaling pathway and tumor growth. Many TKIs got approved by FDA in recent times for the …