Looping the genome with SMC complexes
SMC (structural maintenance of chromosomes) protein complexes are an evolutionarily
conserved family of motor proteins that hold sister chromatids together and fold genomes …
conserved family of motor proteins that hold sister chromatids together and fold genomes …
A walk through the SMC cycle: From catching DNAs to shaping the genome
R Oldenkamp, BD Rowland - Molecular cell, 2022 - cell.com
SMC protein complexes are molecular machines that provide structure to chromosomes.
These complexes bridge DNA elements and by doing so build DNA loops in cis and hold …
These complexes bridge DNA elements and by doing so build DNA loops in cis and hold …
The SMC-family Wadjet complex protects bacteria from plasmid transformation by recognition and cleavage of closed-circular DNA
Self versus non-self discrimination is a key element of innate and adaptive immunity across
life. In bacteria, CRISPR-Cas and restriction-modification systems recognize non-self nucleic …
life. In bacteria, CRISPR-Cas and restriction-modification systems recognize non-self nucleic …
CTCF is a DNA-tension-dependent barrier to cohesin-mediated loop extrusion
In eukaryotes, genomic DNA is extruded into loops by cohesin. By restraining this process,
the DNA-binding protein CCCTC-binding factor (CTCF) generates topologically associating …
the DNA-binding protein CCCTC-binding factor (CTCF) generates topologically associating …
All eukaryotic SMC proteins induce a twist of− 0.6 at each DNA loop extrusion step
Eukaryotes carry three types of structural maintenance of chromosome (SMC) protein
complexes, condensin, cohesin, and SMC5/6, which are ATP-dependent motor proteins that …
complexes, condensin, cohesin, and SMC5/6, which are ATP-dependent motor proteins that …
[HTML][HTML] SMC complexes can traverse physical roadblocks bigger than their ring size
Ring-shaped structural maintenance of chromosomes (SMC) complexes like condensin and
cohesin extrude loops of DNA. It remains, however, unclear how they can extrude DNA …
cohesin extrude loops of DNA. It remains, however, unclear how they can extrude DNA …
CTCF and R-loops are boundaries of cohesin-mediated DNA looping
Cohesin and CCCTC-binding factor (CTCF) are key regulatory proteins of three-dimensional
(3D) genome organization. Cohesin extrudes DNA loops that are anchored by CTCF in a …
(3D) genome organization. Cohesin extrudes DNA loops that are anchored by CTCF in a …
How do molecular motors fold the genome?
Many protein complexes that drive key processes in cells are “molecular motors”—
assemblies that consume (electro) chemical energy to produce mechanical work. Examples …
assemblies that consume (electro) chemical energy to produce mechanical work. Examples …
Establishment of dsDNA-dsDNA interactions by the condensin complex
Condensin is a structural maintenance of chromosomes (SMC) complex family member
thought to build mitotic chromosomes by DNA loop extrusion. However, condensin variants …
thought to build mitotic chromosomes by DNA loop extrusion. However, condensin variants …
Single cohesin molecules generate force by two distinct mechanisms
Spatial organization of DNA is facilitated by cohesin protein complexes that move on DNA
and extrude DNA loops. How cohesin works mechanistically as a molecular machine is …
and extrude DNA loops. How cohesin works mechanistically as a molecular machine is …