Innovative medicinal chemistry strategies for enhancing drug solubility

Z He, W Yang, F Yang, J Zhang, L Ma - European Journal of Medicinal …, 2024 - Elsevier
Drug candidates with poor solubility have been recognized as the cause of many drug
development failures, owing to the fact that low solubility is unfavorable for physicochemical …

Photoredox/Iron Dual-Catalysis-Enabled [4+ 2] Cyclization of Acyl Nitrene with Alkynes

S Xie, S Tang, M Hou, W Xie, M Guan, T Bai, L He… - Organic …, 2024 - ACS Publications
In this work, the annulation of acyl nitrene with alkynes is reported under photoredox/iron
dual-catalysis for the synthesis of a series of isoquninalin-2-ones. The reaction is featured …

Functionalized quinolones and isoquinolones via 1, 2-difunctionalization of arynes: synthesis of antagonist agent AS2717638 and floxacin key intermediates

SD Mahale, A Prasad, SB Mhaske - Chemical Communications, 2025 - pubs.rsc.org
Quinolones and isoquinolones are privileged scaffolds in synthetic/medicinal chemistry and
drug discovery due to their unique chemical structures and intrinsic properties. Herein, we …

Fluoroalkoxylated C-3 and C-9 (S)-12-bromostepholidine analogues with D1R antagonist activity

HK Namballa, AM Decker, M Dorogan, A Gudipally… - Bioorganic …, 2023 - Elsevier
To illuminate the tolerance of fluoroalkoxylated groups at the C-3 and C-9 positions of
tetrahydroprotoberberines (THPBs) on D1R activity, C-3 and C-9 fluoroalkoxylated …

Lysophospholipid (S1P) receptors in GtoPdb v. 2023.1

V Blaho, J Chun, D Herr, D Jones… - IUPHAR/BPS Guide …, 2023 - journals.ed.ac.uk
Abstract Sphingosine 1-phosphate (S1P) receptors (nomenclature as agreed by the NC-
IUPHAR Subcommittee on Lysophospholipid receptors [96]) are activated by the …