Therapeutic targets and biomarkers of tumor immunotherapy: response versus non-response
DR Wang, XL Wu, YL Sun - Signal transduction and targeted therapy, 2022 - nature.com
Cancers are highly complex diseases that are characterized by not only the overgrowth of
malignant cells but also an altered immune response. The inhibition and reprogramming of …
malignant cells but also an altered immune response. The inhibition and reprogramming of …
Nonequilibrium physics in biology
X Fang, K Kruse, T Lu, J Wang - Reviews of Modern Physics, 2019 - APS
Life is characterized by a myriad of complex dynamic processes allowing organisms to grow,
reproduce, and evolve. Physical approaches for describing systems out of thermodynamic …
reproduce, and evolve. Physical approaches for describing systems out of thermodynamic …
Novel in silico tools for designing peptide-based subunit vaccines and immunotherapeutics
The conventional approach for designing vaccine against a particular disease involves
stimulation of the immune system using the whole pathogen responsible for the disease. In …
stimulation of the immune system using the whole pathogen responsible for the disease. In …
In silico simulation of a clinical trial with anti-CTLA-4 and anti-PD-L1 immunotherapies in metastatic breast cancer using a systems pharmacology model
The low response rate of immune checkpoint blockade in breast cancer has highlighted the
need for predictive biomarkers to identify responders. While a number of clinical trials are …
need for predictive biomarkers to identify responders. While a number of clinical trials are …
[HTML][HTML] Prospect for application of mathematical models in combination cancer treatments
The long-term efficacy of targeted therapeutics for cancer treatment can be significantly
limited by the type of therapy and development of drug resistance, inter alia. Experimental …
limited by the type of therapy and development of drug resistance, inter alia. Experimental …
Current progress in pharmacokinetic studies of vaccines: Impact of carrier, ADME and its modulation on immune responses
The lack of knowledge about the absorption, distribution, metabolism, and excretion (ADME)
of vaccines makes biopharmaceutical optimization difficult. This was shown during the …
of vaccines makes biopharmaceutical optimization difficult. This was shown during the …
The potential of computational modeling to predict disease course and treatment response in patients with relapsing multiple sclerosis
As of today, 20 disease-modifying drugs (DMDs) have been approved for the treatment of
relapsing multiple sclerosis (MS) and, based on their efficacy, they can be grouped into …
relapsing multiple sclerosis (MS) and, based on their efficacy, they can be grouped into …
A comprehensive review on pharmacokinetic studies of vaccines: impact of delivery route, carrier-and its modulation on immune response.
The lack of knowledge about the absorption, distribution, metabolism, and excretion (ADME)
of vaccines makes former biopharmaceutical optimization difficult. This was shown during …
of vaccines makes former biopharmaceutical optimization difficult. This was shown during …
Towards the knowledge-based design of universal influenza epitope ensemble vaccines
QM Sheikh, D Gatherer, PA Reche, DR Flower - Bioinformatics, 2016 - academic.oup.com
Motivation: Influenza A viral heterogeneity remains a significant threat due to unpredictable
antigenic drift in seasonal influenza and antigenic shifts caused by the emergence of novel …
antigenic drift in seasonal influenza and antigenic shifts caused by the emergence of novel …
Current strategies and applications for precision drug design
C Wang, P Xu, L Zhang, J Huang, K Zhu… - Frontiers in …, 2018 - frontiersin.org
Since Human Genome Project (HGP) revealed the heterogeneity of individuals, precision
medicine that proposes the customized healthcare has become an intractable and hot …
medicine that proposes the customized healthcare has become an intractable and hot …