Actin dynamics in cell migration
Cell migration is an essential process, both in unicellular organisms such as amoeba and as
individual or collective motility in highly developed multicellular organisms like mammals. It …
individual or collective motility in highly developed multicellular organisms like mammals. It …
Assembling actin filaments for protrusion
Cell migration entails a plethora of activities combining the productive exertion of protrusive
and contractile forces to allow cells to push and squeeze themselves through cell clumps …
and contractile forces to allow cells to push and squeeze themselves through cell clumps …
HEM1 deficiency disrupts mTORC2 and F-actin control in inherited immunodysregulatory disease
SA Cook, WA Comrie, MC Poli, M Similuk, AJ Oler… - Science, 2020 - science.org
Immunodeficiency often coincides with hyperactive immune disorders such as autoimmunity,
lymphoproliferation, or atopy, but this coincidence is rarely understood on a molecular level …
lymphoproliferation, or atopy, but this coincidence is rarely understood on a molecular level …
WAVE regulatory complex
Dynamic rearrangement of the actin cytoskeleton drives a myriad of processes in eukaryotic
cells, such as cell migration and vesicle trafficking, and its dysregulation is deeply …
cells, such as cell migration and vesicle trafficking, and its dysregulation is deeply …
Structural organization of the retriever–CCC endosomal recycling complex
The recycling of membrane proteins from endosomes to the cell surface is vital for cell
signaling and survival. Retriever, a trimeric complex of vacuolar protein-sorting-associated …
signaling and survival. Retriever, a trimeric complex of vacuolar protein-sorting-associated …
Structures reveal a key mechanism of WAVE regulatory complex activation by Rac1 GTPase
Abstract The Rho-family GTPase Rac1 activates the WAVE regulatory complex (WRC) to
drive Arp2/3 complex-mediated actin polymerization in many essential processes. Rac1 …
drive Arp2/3 complex-mediated actin polymerization in many essential processes. Rac1 …
Forces generated by lamellipodial actin filament elongation regulate the WAVE complex during cell migration
Actin filaments generate mechanical forces that drive membrane movements during
trafficking, endocytosis and cell migration. Reciprocally, adaptations of actin networks to …
trafficking, endocytosis and cell migration. Reciprocally, adaptations of actin networks to …
RAC1P29S induces a mesenchymal phenotypic switch via serum response factor to promote melanoma development and therapy resistance
RAC1 P29 is the third most commonly mutated codon in human cutaneous melanoma, after
BRAF V600 and NRAS Q61. Here, we study the role of RAC1 P29S in melanoma …
BRAF V600 and NRAS Q61. Here, we study the role of RAC1 P29S in melanoma …
WASP family proteins: Molecular mechanisms and implications in human disease
Abstract Proteins of the Wiskott-Aldrich syndrome protein (WASP) family play a central role
in regulating actin cytoskeletal dynamics in a wide range of cellular processes. Genetic …
in regulating actin cytoskeletal dynamics in a wide range of cellular processes. Genetic …
Origin, organization, dynamics, and function of actin and actomyosin networks at the T cell immunological synapse
The engagement of a T cell with an antigen-presenting cell (APC) or activating surface
results in the formation within the T cell of several distinct actin and actomyosin networks …
results in the formation within the T cell of several distinct actin and actomyosin networks …