Clefts of the lip and/or palate (CLP) are common birth defects of complex aetiology. CLP can
occur in isolation or as part of a broad range of chromosomal, Mendelian or teratogenic …

Many environmental risk factors for common, complex human diseases have been revealed
by epidemiologic studies, but how genotypes at specific loci modulate individual responses …

Cleft of the lip with or without cleft palate (CL/P) represents one of the commonest congenital
malformations in Western countries. Based on their association with specific malformative …

Nonsyndromic orofacial clefts have a multifactorial etiology, involving both genetic and
environmental factors. Although linkage and candidate gene studies have attempted to …

ABSTRACT INTRODUCTION: Cleft lip and/or palate (CL/P) represent the most common
congenital anomalies of the face. OBJECTIVE: To assess the relationship between maternal …

The zebrafish is an appealing model organism for investigating the genetic (G) and
environmental (E) factors, as well as their interactions (GxE), which contribute to craniofacial …

Orofacial clefting is a common birth defect with significant morbidity. A panoply of candidate
genes have been discovered through synergy of animal models and human genetics …

Background Non-syndromic clefts lip and/or palate (CL/P) defects may have manifold
significant and detrimental consequences for the affected individuals and their family …

Background While there is strong evidence that genetic risk factors play an important role in
the etiologies of structural birth defects, compared to other diseases, there have been …

Human facial morphology is a combination of many complex traits. Little is known about the
genetic basis of common facial morphological variation. Existing association studies have …