Following successful gene rearrangement at αβ T-cell receptor (TCR) loci, developing
thymocytes express both CD4 and CD8 co-receptors and undergo a life-or-death selection …

Many advances in our understanding of the molecules that regulate the development,
differentiation and function of T cells have been made over the past few years. One …

Several studies have shown that tRNAs can be enzymatically cleaved to generate distinct
classes of tRNA-derived fragments (tRF). Here, we report that tRF/miR-1280, a 17-bp …

The zinc-finger transcription factor GATA-3 has received much attention as a master
regulator of T helper 2 (Th2) cell differentiation, during which it controls interleukin-4 (IL-4) …

It has been almost a quarter century since it was first appreciated that a class of oncogenes
contained in rapidly transforming avian retroviruses encoded DNA-binding transcription …

Group 2 innate lymphoid cells (ILC2s; also called nuocytes, innate helper cells, or natural
helper cells) provide protective immunity during helminth infection and play an important …

The transcription factor GATA-3 is expressed at every stage of thymic development, but its
role in thymocyte differentiation is unknown. The fact that RAG chimeric animals lacking …

GATA3 is an essential transcription factor that was first identified as a regulator of immune
cell function. In recent microarray analyses of human breast tumors, both normal breast …

Macroautophagy serves cellular housekeeping and metabolic functions through delivery of
cytoplasmic constituents for lysosomal degradation. In addition, it may mediate the …

GATA-3 is expressed at higher levels in CD4 than in CD8 SP thymocytes. Here we show that
upregulation of GATA-3 expression in DP thymocytes is triggered by TCR stimulation, and …