Successful use of an artificial placenta–based life support system to treat extremely preterm ovine fetuses compromised by intrauterine inflammation

H Usuda, S Watanabe, M Saito, H Ikeda… - American journal of …, 2020 - Elsevier
Background Ex vivo uterine environment therapy is an experimental intensive care strategy
for extremely preterm infants born between 21 and 24 weeks of gestation. Gas exchange is …

Immune system remodelling by prenatal betamethasone: effects on β-cells and type 1 diabetes

D Perna-Barrull, A Gieras… - Frontiers in …, 2020 - frontiersin.org
Type 1 diabetes (T1D) is a multifactorial disease of unknown aetiology. Studies focusing on
environment-related prenatal changes, which might have an influence on the development …

[HTML][HTML] Glucocorticosteroids effects on brain development in the preterm infant: a role for microglia?

Z Manuela, P Julien, B Elodie, B Olivier… - Current …, 2021 - ncbi.nlm.nih.gov
Prematurity, observed in 15 million births worldwide each year, is a clinical condition that is
a major cause of neonatal mortality and morbidity in the short and long term. Preterm infants …

High-dose dexamethasone injection disordered metabolism and multiple protein kinases expression in the mouse kidney

Z Zhang, Y Ran, L Xu, Z Pan, Y Xie - Bioscience Reports, 2021 - portlandpress.com
Glucocorticoids (GCs) have been widely used in clinical treatment as anti-inflammatory, anti-
shock and immunosuppressive medicines. However, the effect of excessive GCs on immune …

Long-term and high dose dexamethasone injection decreases the expression of Immunoglobulin Heavy (Light) Chain Variable Region Genes (IGH (L) Vs) in the …

Y Qi, Q Yi, Y Liu, Y Hu, D Ni, J Liu, Q Zhou, Y Xie - Gene, 2019 - Elsevier
Glucocorticoid hormones have been widely used in clinical practice as potent anti-
inflammatory and immunosuppressive agents. However, the underlying mechanisms of how …

Effects of postnatal hydrocortisone on cytokine profile in extremely preterm infants

K Tamura, M Nagaoka, S Inomata… - Pediatrics …, 2022 - Wiley Online Library
Background Systemic hydrocortisone administration has been widely used in preterm
infants who are at risk of bronchopulmonary dysplasia (BPD). However, the effects of …

Antenatal corticosteroids‐to‐delivery interval associates cord blood S100B levels

K Fuma, T Kotani, T Ushida, K Imai… - Journal of Obstetrics …, 2023 - Wiley Online Library
Aim Antenatal corticosteroids (ACS) are recommended for women at risk of preterm birth
before 34 weeks' gestation. However, adverse effects of ACS on the fetal brain have also …

[HTML][HTML] Extreme prematurity-associated alterations of pulmonary inflammatory mediators before and after surfactant administration

R Mehta, A Purohit, A Petrova - Pediatrics & Neonatology, 2023 - Elsevier
Background The role of prematurity and pulmonary inflammation in the pathogenesis of
bronchopulmonary dysplasia (BPD) is very well-defined. However, there is limited …

Effect of antenatal betamethasone on early systemic inflammatory indices in preterm infants with gestational age< 32 weeks

U Cakir, C Tayman - Journal of Pediatric and Neonatal Individualized …, 2024 - jpnim.com
Introduction: Antenatal glucocorticoid (AGC) therapy is routinely given to pregnant women
when preterm delivery is expected. Systemic inflammatory indices are thought to have …

The effect of antenatal steroid therapy on early inflammation markers and leukocyte counts in premature infants

E Beser Ozmen, G Kadioglu Simsek… - Fetal and Pediatric …, 2022 - Taylor & Francis
Objective We investigated the effect of antenatal steroid therapy (AST) on white blood cell
(WBC) and neutrophil counts and the inflammatory markers C-reactive protein (CRP) …