Abstract Calcium (Ca2+) signalling is of paramount importance to immunity. Regulated
increases in cytosolic and organellar Ca2+ concentrations in lymphocytes control complex …

Ca 2+ is a ubiquitous intracellular messenger that controls diverse cellular functions but can
become toxic and cause cell death. Selective control of specific targets depends on …

We report the updated classification of inborn errors of immunity, compiled by the
International Union of Immunological Societies Expert Committee. This report documents the …

Dental enamel is the hardest and most mineralized tissue in extinct and extant vertebrate
species and provides maximum durability that allows teeth to function as weapons and/or …

Stimulator of interferon genes (STING) is an endoplasmic reticulum (ER) signaling adaptor
that is essential for the type I interferon response to DNA pathogens. Aberrant activation of …

Calcium (Ca 2+) signals play fundamental roles in immune cell function. The main sources
of Ca 2+ influx in mammalian lymphocytes following antigen receptor stimulation are Ca 2+ …

T cell antigen-receptor (TCR) signaling controls the development, activation and survival of
T cells by involving several layers and numerous mechanisms of gene regulation. N 6 …

In recent years, rapid discoveries have been made relating to Ca 2+ handling at specific
organelles that have important implications for whole-cell Ca 2+ homeostasis. In particular …

The primary immunodeficiency diseases (PIDs) include many genetic disorders that affect
different components of the innate and adaptive responses. The number of distinct genetic …

The congenital myopathies are a group of early-onset, non-dystrophic neuromuscular
conditions with characteristic muscle biopsy findings, variable severity and a stable or slowly …