The lipid A moiety of lipopolysaccharide forms the outer monolayer of the outer membrane of
most gram-negative bacteria. Escherichia coli lipid A is synthesized on the cytoplasmic …

The genomics revolution has unveiled a wealth of poorly characterized proteins. Scientists
are often able to produce milligram quantities of proteins for which function is unknown or …

The targets of the Structural GenomiX (SGX) bacterial genomics project were proteins
conserved in multiple prokaryotic organisms with no obvious sequence homolog in the …

Modification of the phosphate groups of lipid A with 4-amino-4-deoxy-l-arabinose (l-Ara4N)
is required for resistance to polymyxin and cationic antimicrobial peptides in Escherichia coli …

Modification of lipid A with the 4-amino-4-deoxy-l-arabinose (l-Ara4N) moiety is required for
resistance to polymyxin and cationic antimicrobial peptides in Escherichia coli and …

Helicobacter pylori and Campylobacter jejuni have been shown to modify their flagellins
with pseudaminic acid (Pse), via O-linkage, while C. jejuni also possesses a general protein …

The interactions between bacterial pathogens and their eukaryotic hosts are vital in
determining the outcome of infections. Bacterial pathogens employ molecular sensors to …

Covering: up to 2012 The glycosylation of microbial natural products often dramatically
influences the biological and/or pharmacological activities of the parental metabolite. Over …

The biosynthetic gene cluster for the enediyne antitumor antibiotic maduropeptin (MDP) from
Actinomadura madurae ATCC 39144 was cloned and sequenced. Cloning of the mdp gene …

In Escherichia coli and Salmonella typhimurium, addition of the 4-amino-4-deoxy-l-
arabinose (l-Ara4N) moiety to the phosphate group (s) of lipid A is required for resistance to …