International Union of Basic and Clinical Pharmacology. LXXXIX. Update on the extended family of chemokine receptors and introducing a new nomenclature for …
F Bachelerie, A Ben-Baruch, AM Burkhardt… - Pharmacological …, 2014 - ASPET
Sixteen years ago, the Nomenclature Committee of the International Union of Pharmacology
approved a system for naming human seven-transmembrane (7TM) G protein-coupled …
approved a system for naming human seven-transmembrane (7TM) G protein-coupled …
[HTML][HTML] Mechanisms of age-related macular degeneration
J Ambati, BJ Fowler - Neuron, 2012 - cell.com
Age-related macular degeneration (AMD), a progressive condition that is untreatable in up
to 90% of patients, is a leading cause of blindness in the elderly worldwide. The two forms of …
to 90% of patients, is a leading cause of blindness in the elderly worldwide. The two forms of …
Immunology of age-related macular degeneration
J Ambati, JP Atkinson, BD Gelfand - Nature Reviews Immunology, 2013 - nature.com
Age-related macular degeneration (AMD) is a leading cause of blindness in aged
individuals. Recent advances have highlighted the essential role of immune processes in …
individuals. Recent advances have highlighted the essential role of immune processes in …
LRG1 promotes angiogenesis by modulating endothelial TGF-β signalling
Aberrant neovascularization contributes to diseases such as cancer, blindness and
atherosclerosis, and is the consequence of inappropriate angiogenic signalling. Although …
atherosclerosis, and is the consequence of inappropriate angiogenic signalling. Although …
[HTML][HTML] DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88
Alu RNA accumulation due to DICER1 deficiency in the retinal pigmented epithelium (RPE)
is implicated in geographic atrophy (GA), an advanced form of age-related macular …
is implicated in geographic atrophy (GA), an advanced form of age-related macular …
[HTML][HTML] The mouse retina as an angiogenesis model
The mouse retina has been used extensively over the past decades to study both
physiologic and pathologic angiogenesis. Over time, various mouse retina models have …
physiologic and pathologic angiogenesis. Over time, various mouse retina models have …
DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration
Geographic atrophy (GA), an untreatable advanced form of age-related macular
degeneration, results from retinal pigmented epithelium (RPE) cell degeneration. Here we …
degeneration, results from retinal pigmented epithelium (RPE) cell degeneration. Here we …
Ophthalmic drug discovery: novel targets and mechanisms for retinal diseases and glaucoma
Blindness affects 60 million people worldwide. The leading causes of irreversible blindness
include age-related macular degeneration, retinal vascular diseases and glaucoma. The …
include age-related macular degeneration, retinal vascular diseases and glaucoma. The …
Animal models of choroidal and retinal neovascularization
HE Grossniklaus, SJ Kang, L Berglin - Progress in retinal and eye research, 2010 - Elsevier
There have been numerous types of animal models of choroidal neovascularization (CNV)
and retinal neovascularization (RNV). Understanding the pathobiology of CNV and RNV is …
and retinal neovascularization (RNV). Understanding the pathobiology of CNV and RNV is …
[HTML][HTML] Chemokine mediated monocyte trafficking into the retina: role of inflammation in alteration of the blood-retinal barrier in diabetic retinopathy
S Rangasamy, PG McGuire, C Franco Nitta… - PloS one, 2014 - journals.plos.org
Inflammation in the diabetic retina is mediated by leukocyte adhesion to the retinal
vasculature and alteration of the blood-retinal barrier (BRB). We investigated the role of …
vasculature and alteration of the blood-retinal barrier (BRB). We investigated the role of …