ABSTRACT Selenoprotein GPX4 (glutathione peroxidase 4), originally known as PHGPX
(phospholipid hydroperoxide glutathione peroxidase), is the main oxidoreductase in the use …

It has been widely known that oxidative stress disrupts the balance between reactive oxygen
species (ROS) and the antioxidant system in the body. During pregnancy, the physiological …

Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated from
aerobic metabolism, as a result of accidental electron leakage as well as regulated …

Reactive oxygen species (ROS) are generated as by-products of aerobic respiration and
metabolism. Mammalian cells have evolved a variety of enzymatic mechanisms to control …

Selenium (Se) is a trace element essential for the appropriate course of vital processes in
the human body. It is also a constituent of the active center of glutathione peroxidase that …

The purification of a protein inhibiting lipid peroxidation led to the discovery of the
selenoperoxidase GPx4 forty years ago. Thus, the evidence of the enzymatic activity was …

Ferroptosis is a nonapoptotic form of cell death characterized by the iron-dependent
accumulation of toxic lipid reactive oxygen species. Small-molecule screening and …

Abstract Targeting Glutathione peroxidase 4 (GPX4) has become a promising strategy for
drug-resistant cancer therapy via ferroptosis induction. It was found that the GPX4 inhibitors …

Selenium is linked to male fertility. Glutathione peroxidase 4 (GPx4), first described as an
antioxidant enzyme, is the predominant selenoenzyme in testis and has been suspected of …

Spermatogenesis is a complex process of male germ cells proliferation and maturation from
diploid spermatogonia, through meiosis, to mature haploid spermatozoa. The process …