From discovery to function: the expanding roles of long noncoding RNAs in physiology and disease

M Sun, WL Kraus - Endocrine reviews, 2015 - academic.oup.com
Long noncoding RNAs (lncRNAs) are a relatively poorly understood class of RNAs with little
or no coding capacity transcribed from a set of incompletely annotated genes. They have …

[HTML][HTML] Different pathways of macrophage activation and polarization

U Juhas, M Ryba-Stanisławowska, P Szargiej… - Advances in Hygiene …, 2015 - phmd.pl
Monocytes are short-lived cells and undergo spontaneous apoptosis every day.
Inflammatory responses may induce dramatic up-regulation of monocyte survival and …

Long non-coding RNA ADNCR suppresses adipogenic differentiation by targeting miR-204

M Li, X Sun, H Cai, Y Sun, M Plath, C Li, X Lan… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Adipogenesis is a complex and precisely orchestrated process mediated by a network of
adipogenic regulatory factors. Several studies have highlighted the relevance of lncRNAs in …

Besides pathology: long non-coding RNA in cell and tissue homeostasis

A Salviano-Silva, SC Lobo-Alves, RC Almeida… - Non-coding RNA, 2018 - mdpi.com
A significant proportion of mammalian genomes corresponds to genes that transcribe long
non-coding RNAs (lncRNAs). Throughout the last decade, the number of studies concerning …

Long Non-coding RNA H19 Inhibits Adipocyte Differentiation of Bone Marrow Mesenchymal Stem Cells through Epigenetic Modulation of Histone Deacetylases

Y Huang, Y Zheng, C Jin, X Li, L Jia, W Li - Scientific reports, 2016 - nature.com
Bone marrow mesenchymal stem cells (BMSCs) exhibit an increased propensity toward
adipocyte differentiation accompanied by a reduction in osteogenesis in osteoporotic bone …

Sirt1 AS lncRNA interacts with its mRNA to inhibit muscle formation by attenuating function of miR-34a

G Wang, Y Wang, Y Xiong, XC Chen, M Ma, R Cai… - Scientific reports, 2016 - nature.com
Recent studies demonstrate the functions of long non-coding RNAs (lncRNAs) in mediating
gene expression at the transcriptional or translational level. Our previous study identified a …

Long noncoding RNAs in regulating adipogenesis: new RNAs shed lights on obesity

S Wei, M Du, Z Jiang, GJ Hausman, L Zhang… - Cellular and Molecular …, 2016 - Springer
Long noncoding RNAs (lncRNAs) are an emerging class of regulators involved in a myriad
of biological processes. Recent studies have revealed that many lncRNAs play pivotal roles …

Adiponectin AS lncRNA inhibits adipogenesis by transferring from nucleus to cytoplasm and attenuating Adiponectin mRNA translation

R Cai, Y Sun, N Qimuge, G Wang, Y Wang… - … et Biophysica Acta (BBA …, 2018 - Elsevier
Adiponectin (AdipoQ) is an adipocyte-derived hormone with positive function on systemic
glucose and lipid metabolism. Long noncoding RNA (lncRNA) is emerging as a vital …

The regulatory role of long noncoding RNAs in cancer

Y Tang, BB Cheung, B Atmadibrata, GM Marshall… - Cancer letters, 2017 - Elsevier
With the advances in genomic analysis technologies, especially next-generation RNA
sequencing, a large number of new transcripts have been discovered, leading to better …

[HTML][HTML] Long noncoding RNA: multiple players in gene expression

X Chen, Y Sun, R Cai, G Wang, X Shu, W Pang - BMB reports, 2018 - ncbi.nlm.nih.gov
Previously considered as a component of transcriptional noise, long noncoding RNAs
(lncRNAs) were neglected as a therapeutic target, however, recently increasing evidence …