Since the discovery of indoleamine 2, 3-dioxygenase 1 (IDO1) as an attractive target for
anticancer therapy in 2003, the search for inhibitors has been intensely pursued both in …

Indoleamine 2, 3-dioxygenase 1 (IDO1), an important immunoregulatory enzyme
ubiquitously expressed in various tissues and cells, plays a key role in tryptophan …

The di-2-pyridylketone thiosemicarbazones demonstrated marked anticancer efficacy,
prompting progression of DpC to clinical trials. However, DpC induced deleterious oxy …

According to the pharmacophore binding strategy and principle of bioelectronic isobaric,
used the sulfonylurea bridge as the parent structure, a series of novel thiourea compounds …

Abstract Thiosemicarbazides (TSCs), dithiocarbamates (DTCs) and their molecular
conjugates are promising drug targets. However, hybrids of DTCs with TSCs themselves are …

A series of coumarin derivatives were designed, synthesized, and evaluated for their
antiproliferative activity. Compound 3e exhibited significant antiproliferative activity and was …

In this work, novel 5-fluoro-1-methyl/ethyl-1H-indole-2, 3-dione 3-[4-(substituted phenyl)-
thiosemicarbazones] 6a-n and 7a-n were synthesized. The antiviral effects of the …

MAO-B inhibitors are frequently used in the treatment of neurodegenerative diseases such
as Parkinson's and Alzheimer's. Due to the limited number of compounds available in this …

Two new thiosemicarbazone ligands {HL 1= 4‑(2‑chlorophenyl)‑1‑((pyridin‑2‑yl) methylene)
thiosemicarbazide and HL 2= 4‑(2‑methoxyphenyl)‑1‑((pyridin‑2‑yl) methylene) …

Abstract d-Alanyl-d-alanine ligase (Ddl) is a validated and attractive target among the
bacterial enzymes involved in peptidoglycan biosynthesis. In the present work, we …