Alcohol is a widely used and abused substance with numerous negative consequences for
human health and safety. Historically, alcohol's widespread, non-specific neurobiological …

Addiction is a progressive and complex disease that encompasses a wide range of
disorders and symptoms, including substance use disorder (SUD), for which there are few …

Binge alcohol consumption among adolescents affects the developing neural networks
underpinning reward and stress processing in the nucleus accumbens (NAc). This study …

Alcohol use disorder (AUD) exacts an immense toll on individuals, families, and society.
Genetic factors determine up to 60% of an individual's risk of developing problematic alcohol …

Rho GTPases family are considered to be molecular switches that regulate various cellular
processes, including cytoskeleton remodeling, cell polarity, synaptic development and …

Drug addiction and the circuitry for learning and memory are intimately intertwined. Drugs of
abuse create strong, inappropriate, and lasting memories that contribute to many of their …

Gene expression studies offer promising opportunities to better understand the processes
underlying alcohol use disorder (AUD). As cell types differ in their function, gene expression …

An understanding of neuroimmune signaling has become central to a description of how
alcohol causes addiction and how it damages people with an AUD. It is well known that the …

Substance use disorders (SUD) are chronic relapsing disorders governed by continually
shifting cycles of positive drug reward experiences and drug withdrawal-induced negative …

Background Lipid levels are maintained by balancing lipid uptake, synthesis, and
mobilization. Although many studies have focused on the control of lipid synthesis and …