Identification and management of alcohol withdrawal syndrome

A Mirijello, C D'Angelo, A Ferrulli, G Vassallo… - Drugs, 2015 - Springer
Symptoms of alcohol withdrawal syndrome (AWS) may develop within 6–24 h after the
abrupt discontinuation or decrease of alcohol consumption. Symptoms can vary from …

[HTML][HTML] Alcohol withdrawal syndrome: benzodiazepines and beyond

A Sachdeva, M Choudhary… - Journal of clinical and …, 2015 - ncbi.nlm.nih.gov
Alcohol dependence is an increasing and pervasive problem. Alcohol withdrawal symptoms
are a part of alcohol dependence syndrome and are commonly encountered in general …

[HTML][HTML] Alcohol withdrawal syndrome

M Bayard, J Mcintyre, KR Hill… - American family …, 2004 - aafp.org
Alcohol Withdrawal Syndrome | AAFP Advertisement search close brand logo MAX
BAYARD, MD, JONAH MCINTYRE, MD, KEITH R. HILL, MD, AND JACK WOODSIDE, JR …

Baclofen efficacy in reducing alcohol craving and intake: a preliminary double-blind randomized controlled study

G Addolorato, F Caputo, E Capristo… - Alcohol and …, 2002 - academic.oup.com
Aims: The γ-aminobutyric acid (GABAB) receptor agonist, baclofen, has recently been
shown to reduce alcohol intake in alcohol-preferring rats and alcohol consumption and …

Neurocircuitry of alcohol addiction: synthesis from animal models

GF Koob - Handbook of clinical neurology, 2014 - Elsevier
Alcoholism, more generically drug addiction, can be defined as a chronically relapsing
disorder characterized by:(1) compulsion to seek and take the drug (alcohol);(2) loss of …

Complete and prolonged suppression of symptoms and consequences of alcohol-dependence using high-dose baclofen: a self-case report of a physician

O Ameisen - Alcohol and alcoholism, 2005 - academic.oup.com
Aims: To test whether the dose-dependent motivation-suppressing effect of baclofen in
animals could be transposed to humans, and suppress craving and sustain abstinence …

A role for GABA mechanisms in the motivational effects of alcohol

GF Koob - Biochemical pharmacology, 2004 - Elsevier
Low doses of ethanol have been hypothesized to act directly via proteins that form ligand-
gated receptor channels, such as the γ-aminobutyric acid (GABA) receptor complex, to …

Baclofen for alcohol withdrawal

J Liu, LN Wang - Cochrane database of systematic reviews, 2019 - cochranelibrary.com
Background Alcohol withdrawal syndrome (AWS) is a distressing and life‐threatening
condition that usually affects people who are alcohol dependent when they discontinue or …

Baclofen in the treatment of alcohol withdrawal syndrome: a comparative study vs diazepam

G Addolorato, L Leggio, L Abenavoli, R Agabio… - The American journal of …, 2006 - Elsevier
PURPOSE: Benzodiazepines are the drugs of choice in the treatment of alcohol withdrawal
syndrome (AWS). Recent data have shown that baclofen may reduce AWS symptoms. At …

The γ‐Aminobutyric Acid‐B Receptor Agonist Baclofen Attenuates Responding for Ethanol in Ethanol‐Dependent Rats

BM Walker, GF Koob - Alcoholism: Clinical and Experimental …, 2007 - Wiley Online Library
Background: γ‐Aminobutyric acid‐B (GABAB) receptor agonists have been shown to
suppress operant self‐administration of ethanol in nondependent rats. However, little work …