Extracellular matrix (ECM) is a dynamic 3‐dimensional network of macromolecules that
provides structural support for the cells and tissues. Accumulated knowledge clearly …

Drug discovery is adapting to novel technologies such as data science, informatics, and
artificial intelligence (AI) to accelerate effective treatment development while reducing costs …

Novel effective treatment is direly needed for patients with pancreatic ductal
adenocarcinoma (PDAC). Therapeutics that target the driver mutations, especially the KRAS …

Collagen, an extracellular protein, covers the entire human body and has several important
biological functions in normal physiology. Recently, collagen from non-human sources has …

Cardiac stress can induce morphological, structural and functional changes of the heart,
referred to as cardiac remodeling. Myocardial infarction or sustained overload as a result of …

Biomechanical and biochemical cues within a tissue collaborate across length scales to
direct cell fate during development and are critical for the maintenance of tissue …

Interventions that delay ageing mobilize mechanisms that protect and repair cellular
components,,, but it is unknown how these interventions might slow the functional decline of …

Molecular biomarkers that predict disease progression might promote drug development
and therapeutic strategies in aggressive cancers, such as gastric cancer (GC). High …

Dynamic and heterogeneous interaction between tumor cells and the surrounding
microenvironment fuels the occurrence, progression, invasion, and metastasis of solid …

Emerging evidence suggests that altered components and posttranslational modifications of
proteins in the extracellular matrix (ECM) may both initiate and drive disease progression …