Ubiquitin signaling is a conserved, widespread, and dynamic process in which protein
substrates are rapidly modified by ubiquitin to impact protein activity, localization, or stability …

The innate and adaptive immune cells have complex signaling pathways for sensing and
initiating immune responses against disease. These pathways are interrupted at different …

Ovarian granulosa cells (GCs) proliferate and differentiate along with follicular growth, and
this is indispensable for oocyte development and female fertility. Although the role of …

Depletion of CD8+ T cells is a major obstacle in immunotherapy; however, the relevant
mechanisms remain largely unknown. Here, we showed that prostate cancer (PCa) cell …

Survivin is a component of the chromosomal passenger complex, which includes Aurora B,
INCENP, and Borealin, and is required for chromosome segregation and cytokinesis. We …

CDC14, originally identified as crucial mediator of mitotic exit in budding yeast, belongs to
the family of dual‐specificity phosphatases (DUSPs) that are present in most eukaryotes …

Background: Limited therapeutic options are available for advanced LUAD without driver
gene mutations. Anti-CDK therapy has shown effectiveness in several kind of cancers …

Ubiquitin‑specific peptidase 9X (USP9X) is involved in certain human diseases, including
malignancies, atherosclerosis and certain diseases of the nervous system. USP9X promotes …

Mammalian target of rapamycin (mTOR) is a central regulator of mammalian metabolism
and physiology. Aberrant hyperactivation of the mTOR pathway promotes tumor growth and …

The mechanisms underlying the development and progression of colon cancer are not fully
understood. Herein, Src kinase associated phosphoprotein 1 (SKAP1), an immune cell …