Physiological Effects of TolC‐Dependent Multidrug Efflux Pumps in Escherichia coli: Impact on Motility and Growth Under Stress Conditions

AM Di Maso, C Ruiz - MicrobiologyOpen, 2024 - Wiley Online Library
Enterobacteriaceae possess eight TolC‐dependent multidrug efflux pumps: AcrAB‐TolC,
AcrAD‐TolC, AcrEF‐TolC, MdtEF‐TolC, MdtABC‐TolC, EmrAB‐TolC, EmrYK‐TolC, and …

Temporally variable drug profiles select for diverse adaptive pathways despite conservation of efflux-based resistance mechanism

Akanksha, S Mehra - bioRxiv, 2023 - biorxiv.org
Antibiotic resistance is a global health concern with emergence of resistance in bacteria out-
competing the discovery of novel drug candidates. While Adaptive Laboratory Evolution …