The inflammaging concept was introduced in 2000 by Prof. Franceschi. This was an
evolutionary or rather a revolutionary conceptualization of the immune changes in response …

Human coronaviruses (HCoVs) are known respiratory pathogens associated with a range of
respiratory outcomes. In the past 14 years, the onset of severe acute respiratory syndrome …

The human gastrointestinal tract is inhabited by a vast number of microorganisms that are
called as the microbiota. Each individual harbors a unique gut microbial composition, this …

Middle East respiratory syndrome coronavirus (MERS‐CoV) first emerged in late 2012.
Since its emergence, a total of 2279 patients from 27 countries have been infected across …

Flavonoids represent an important group of bioactive compounds derived from plant-based
foods and beverages with known biological activity in cells. From the modulation of …

The human gut is densely populated by commensal and symbiotic microbes (the “gut
microbiota”), with the majority of the constituent microorganisms being bacteria …

The symbiotic gut microbiota modulate health and disease of the host through a series of
transgenomic metabolic and immune regulatory axes. We explore connections between …

Highlights•Preclinical studies support us of PI3K inhibitors in autoimmunity and
inflammation.•First in class PI3K inhibitor has been approved for treatment of B cell …

Autoimmune diseases are immune disorders characterized by T cell hyperactivity and B cell
overstimulation leading to overproduction of autoantibodies. Although the pathogenesis of …

Dendritic cells (DC) play a prominent role in the priming of CD8+ T cells. Vaccination is a
promising treatment to boost tumor-specific CD8+ T cells which is crucially dependent on …